150694-40-9

Upstream product

• 150694-17-0 4'-<(3-butyl-5,6-dihydro-6-methyl-5-oxo-4H-1,2,4-oxadiazin-4-yl)methyl><1,1'-biphenyl>-2-carboxylic acid 
• 150694-44-3 2-Pentanimidoylaminooxy-4-phenyl-butyric acid ethyl ester 
• 82586-61-6 ethyl 2-bromo-4-phenylbutanoate 
• 114772-40-6 4'-bromomethyl-biphenyl-2-carboxylic acid tert-butyl ester 
• 150694-39-6 3-butyl-6-(phenylethyl)-4H-1,2,4-oxadiazin-5(6H)-one 
• 67015-06-9 (Z)-N'-hydroxypentanimidamide 

Downstream Products

• 150694-37-4 4'-<<3-butyl-5,6-dihydro-5-oxo-6-(2-phenylethyl)-4H-1,2,4-oxadiazin-4-yl>methyl><1,1'-biphenyl>-2-carboxylic acid 

Relevant academic research and scientific papers

SYNTHESIS OF N-ALKYL-1,2,4-OXADIAZINONES AS ANGIOTENSIN-II (AT1) RECEPTOR ANTAGONISTS

4-Alkyl-1,2,4-oxadiazinones were prepared by regiospecific alkylation of the corresponding 4H-oxadiazinones, which were synthesized by a trimethylaluminium mediated cyclization reaction.Alkylation was regiospecyfic and generally facile; in one example, however, an unusual fragmentation reaction occurred.A homochiral oxadiazineone was also prepared and alkylated under the described conditions. 4-Biphenylmethyl-1,2,4-oxadi-azinones were potent angiotensin-II receptor antagonists.

BIPHENYL OXADIAZINONE ANGIOTENSIN II INHIBITORS

Angiotension II inhibition is exhibited by STR1 wherein: R. sup.1 and R 2 are each independently hydrogen, alkyl, aryl, aralkyl, cycloalkyl, cycloalkylalkyl, thiophenalkyl, pyridylalkyl, or--R 8 CO. sub.2 R 9 ;R 3 is a single bond,--S--, or--O--;