150705-53-6

Basic information

• Product Name: Piperazinone, 1-(2-methylphenyl)- (9CI)
• Synonyms: Piperazinone, 1-(2-methylphenyl)- (9CI)
• CAS NO: 150705-53-6
• Molecular Formula: C₁₁H₁₄N₂O
• Molecular Weight: 190.24166
• Product Categories: PIPERIDINE
• Mol File: 150705-53-6.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Piperazinone, 1-(2-methylphenyl)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Piperazinone, 1-(2-methylphenyl)- (9CI)(150705-53-6)
• EPA Substance Registry System: Piperazinone, 1-(2-methylphenyl)- (9CI)(150705-53-6)

Safety Data

• Hazardous Substances Data: 150705-53-6(Hazardous Substances Data)

Upstream product

• 5625-67-2 2-Ketopiperazine 
• 615-37-2 ortho-methylphenyl iodide 
• 148927-99-5 1-t-butyloxycarbonyl-4-(2-methyl-phenyl)-3-piperazinone 

Downstream Products

• 1146411-33-7 4-[(2-chloro-4-fluorophenyl)carbonyl]-1-(2-methylphenyl)-2-piperazinone 
• 1146411-34-8 4-[(2,3-dichlorophenyl)carbonyl]-1-(2-methylphenyl)-2-piperazinone 

Relevant articles and documents

4-BENZ0YL-1-SUBSTITUTED-PIPERAZIN-2-0NE DERIVATIVES AS P2X7 MODULATORS

The invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof wherein: A is C1-6alkyl, C3-6cycloalkyl, -CH2-R6, -CHMe-R7, -CMe2-R7, or optionally substituted aryl; wherein, when A is optionally substituted aryl, said aryl group is optionally substituted with 1 to 3 substituents, which may be the same or different, selected from the group consisting of halogen, C1-6alkyl, -CF3, C1-4alkoxy, C1fluoroalkoxy, cyano, NR8R9; and pyridyl wherein the pyridyl is optionally substituted by one methyl; R1 is chlorine, fluorine, -CF3, cyano or C1-6alkyl; R2, R3 and R5 independently are hydrogen, fluorine, chlorine, -CF3, cyano or C1-6alkyl, such that at least one of R2, R3 and R5 is other than hydrogen; R4 is hydrogen. These compounds and salts are thought to be P2X7 receptor antagonists. The invention also provides the use of the compound or salt for the manufacture of a medicament for the treatment of pain, inflammation, rheumatoid arthritis, osteoarthritis, or a neurodegenerative disease.