1507136-09-5

Basic information

• Product Name: 7-Trifluoromethyl-imidazo[1,2-a]pyridine-2-carboxylic acid ethyl ester
• Synonyms: 7-Trifluoromethyl-imidazo[1,2-a]pyridine-2-carboxylic acid ethyl ester;ethyl 7-(trifluoromethyl)imidazo[1,2-a]pyridine-2-carboxylate;ethyl 7-(trifluoromethyl)imidazo[1,2-a]pyridine-2-carboxylate(WXC07024)
• CAS NO: 1507136-09-5
• Molecular Formula: C11H9F3N2O2
• Molecular Weight: 258.1965696
• Mol File: 1507136-09-5.mol

Chemical Properties

• Appearance: /
• Density: 1.39±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 0.79±0.50(Predicted)
• CAS DataBase Reference: 7-Trifluoromethyl-imidazo[1,2-a]pyridine-2-carboxylic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 7-Trifluoromethyl-imidazo[1,2-a]pyridine-2-carboxylic acid ethyl ester(1507136-09-5)
• EPA Substance Registry System: 7-Trifluoromethyl-imidazo[1,2-a]pyridine-2-carboxylic acid ethyl ester(1507136-09-5)

Safety Data

• Hazardous Substances Data: 1507136-09-5(Hazardous Substances Data)

Upstream product

• 70-23-5 ethyl Bromopyruvate 
• 106447-97-6 2-amino-4-(trifluoromethyl)pyridine 

Relevant articles and documents

CONDENSED HETEROCYCLIC COMPOUND AND PEST CONTROL AGENT

PROBLEM TO BE SOLVED: To provide a condensed heterocyclic compound and a salt thereof, and a pest control agent containing the compound as an active ingredient. SOLUTION: There is provided the compound of the following general formula (1), for example, 2-[3-(ethylsulfonyl)-7-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl]-7-(trifluoromethyl)imidazo[1,2-c]pyrimidine. In the formula (1), D is a ring represented by any of D1 to D3 and Q is a ring represented by any of Q1 to Q4. SELECTED DRAWING: None COPYRIGHT: (C)2020,JPOandINPIT

CONDENSED HETEROCYCLIC COMPOUNDS AND PESTICIDES

To provide novel pesticides, especially insecticides or acaricides. A condensed heterocyclic compound represented by the formula (1) or its salt or an N-oxide thereof: wherein D substituted with —S(O)nR1 is a ring represented by any one of D1, D2 and D3, Q is a ring represented by any one of Q1, Q2, Q3 and Q4, R1 is C1-C6 alkyl, C1-C6 haloalkyl, (C1-C6) alkyl optionally substituted with R1a, C2-C6 alkenyl, C2-C6 haloalkenyl, C2-C6 alkynyl, C2-C6 haloalkynyl, C3-C6 cycloalkyl, C3-C6 halocycloalkyl, C3-C6 cycloalkyl (C1-C6) alkyl, C3-C6 halocycloalkyl (C1-C6) alkyl or hydroxy (C1-C6) alkyl, R1a is C1-C8 alkoxycarbonyl, and n is an integer of 0, 1 or 2.

FUSED BICYCLIC HETEROCYCLE DERIVATIVES AS PESTICIDES

The invention relates to novel compounds of the formula (I) in which R1, R2, R3, Q and n have the meanings given above, to their use as acaricides and/or insecticides for controlling animal pests and to processes and intermediates for their preparation.

Discovery of imidazopyridine derivatives as highly potent respiratory syncytial virus fusion inhibitors

A series of imidazolepyridine derivatives were designed and synthesized according to the established docking studies. The imidazopyridine derivatives were found to have good potency and physical-chemical properties. Several highly potent compounds such as 8ji, 8jl, and 8jm were identified with single nanomolar activities. The most potent compound 8jm showed an IC50 of 3 nM, lower microsome clearance and no CYP inhibition. The profile of 8jm appeared to be superior to BMS433771, and supported further optimization.