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4-tert-butyl-N-[6-(2-hydroxy-ethoxy)-5-(2-methoxyphenoxy)-2-(thiophen-2-yl)-pyrimidin-4-yl]-benzenesulphonamide is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

150726-32-2

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150726-32-2 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 150726-32-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,0,7,2 and 6 respectively; the second part has 2 digits, 3 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 150726-32:
(8*1)+(7*5)+(6*0)+(5*7)+(4*2)+(3*6)+(2*3)+(1*2)=112
112 % 10 = 2
So 150726-32-2 is a valid CAS Registry Number.

150726-32-2Relevant academic research and scientific papers

Discovery of Ro 48-5695: A potent mixed endothelin receptor antagonist optimized from Bosentan

Neidhart, Werner,Breu, Volker,Burri, Kaspar,Clozel, Martine,Hirth, Georges,Klinkhammer, Uwe,Giller, Thomas,Ramuz, Henri

, p. 2223 - 2228 (2007/10/03)

Implementation of a pyridylcarbamoyl group and an isopropylpyridylsulfonamide substituent as key components in the scaffold of Bosentan resulted in the identification of the potent orally active endothelin receptor antagonist Ro 48-5695. It shows affinities for ET(A) and ET(B) receptors in the low nanomolar range and high functional antagonistic potency in vitro.

SULFONAMIDES

-

, (2008/06/13)

The novel sulfonamides of formula I, STR1 in which the symbols R. sup.1-R 9, R a, R b, X, Y and n have the significance given in the description and salts thereof can be used for the treatment of circulatory disorders, especially hypertension, ischemia, vasopasms and angina pectoris.

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