150726-84-4Relevant academic research and scientific papers
Modifications and structure-activity relationships at the 2-position of 4-sulfonamidopyrimidine derivatives as potent endothelin antagonists
Morimoto, Hiroshi,Shimadzu, Hideshi,Hosaka, Toshihiro,Kawase, Yasushi,Yasuda, Kosuke,Kikkawa, Kohei,Yamauchi-Kohno, Rikako,Yamada, Koichiro
, p. 81 - 84 (2007/10/03)
To improve water solubility and to study structure-activity relationships, we modified the structure of the pyrimidine nucleus of each of a series of potent ETA antagonists, 3a and 4a, at the 2-position. In a previous study, each of these antag
