150730-32-8Relevant academic research and scientific papers
Synthesis and activity of phosphinic tripeptide inhibitors of cathepsin C
Mucha, Artur,Pawelczak, Malgorzata,Hurek, Jozef,Kafarski, Pawel
, p. 3113 - 3116 (2007/10/03)
Phosphinic tripeptide analogues Gly-Xaaψ[P(O)(OH)CH2]-Gly have been developed as inhibitors of cathepsin C (DPP I), a lysosomal, papain-like cysteine protease. The target compounds were synthesised by addition of methyl acrylate to the appropri
Solid phase synthesis of phosphinic peptides
Campagne, Jean-Marc,Coste, Jacques,Guillou, Laurent,Heitz, Annie,Jouin, Patrick
, p. 4181 - 4184 (2007/10/02)
The absence of a coupling reaction between a phosphinic acid and an amino ester during activation with the reagents BOP or PyBOP allowed the synthesis of phosphinopeptides from phospho-analogues of dipeptides, unprotected on the phosphinic acid.
