1507347-40-1Relevant academic research and scientific papers
Electrochemical Difluoromethylation of Electron-Deficient Alkenes
Xu, He-Huan,Song, Jinshuai,Xu, Hai-Chao
, p. 3060 - 3063 (2019)
Electrochemical 1,2-hydroxydifluoromethylation and C?H difluoromethylation of acrylamides were developed by using CF2HSO2NHNHBoc as the source of the CF2H group. These electricity-powered oxidative alkene functionalization reactions do not need transition-metal catalysts or chemical oxidants. The reaction outcome, 1,2-difuntionalization or C?H functionalization, is determined by the substituents on the amide nitrogen atom of the acrylamides instead of by the reaction conditions.
Regio- and diastereoselective cu-mediated trifluoromethylation of functionalized alkenes
Besset, Tatiana,Cahard, Dominique,Pannecoucke, Xavier
, p. 413 - 418 (2014/01/17)
α- and β-substituted N,N-diethylacrylamides undergo copper-mediated direct β-trifluoromethylation. The amide moiety acts as a directing group for the regio- and the stereo-controlled introduction of the trifluoromethyl group. The reaction is carried out u
