150736-72-4

Basic information

• Product Name: N-BOC-(S)-2-AMINO-1-BUTANOL, 96%
• Synonyms: Carbamic acid, [(1S)-1-(hydroxymethyl)propyl]-, 1,1-dimethylethyl ester (9CI);(S)-tert-butyl 1-hydroxybutan-2-ylcarbaMate;CarbaMic acid, N-[(1S)-1-(hydroxyMethyl)propyl]-, 1,1-diMethylethyl ester;Boc-2-Abu-ol
• CAS NO: 150736-72-4
• Molecular Formula: C₉H₁₉NO₃
• Molecular Weight: 189.25206
• Product Categories: N-BOC;Amino Alcohols;Chiral Building Blocks;Organic Building Blocks
• Mol File: 150736-72-4.mol
• Article Data: 24

Chemical Properties

• Melting Point: 40-45 °C
• Boiling Point: 292.9oC at 760 mmHg
• Flash Point: 110 °C
• Appearance: /
• Density: 1.01g/cm3
• Vapor Pressure: 0.000189mmHg at 25°C
• Refractive Index: 1.452
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: N-BOC-(S)-2-AMINO-1-BUTANOL, 96%(CAS DataBase Reference)
• NIST Chemistry Reference: N-BOC-(S)-2-AMINO-1-BUTANOL, 96%(150736-72-4)
• EPA Substance Registry System: N-BOC-(S)-2-AMINO-1-BUTANOL, 96%(150736-72-4)

Safety Data

• Hazard Codes: C
• Statements: 22-34
• Safety Statements: 26-36/37/39-45
• RIDADR: UN 2923 8/PG 3
• WGK Germany: 1
• Hazardous Substances Data: 150736-72-4(Hazardous Substances Data)

Usage

General Description

N-BOC-(S)-2-AMINO-1-BUTANOL, 96% is a chemical compound known for its utilization in chemical and biochemical research and operations. Its primary feature is its chiral center at the 2nd carbon of the butanol chain, providing enantiomeric forms used in chemical analysis and synthesis. N-BOC-(S)-2-AMINO-1-BUTANOL, 96% is often used in pharmaceutical manufacturing, specifically in developing bioactive small molecules. As a protected form of (S)-2-amino-1-butanol, it comes with a blocking group, the BOC group, which shields certain sites in the molecule during synthesis to prevent unwanted reactions. It's noteworthy to mention its purity at 96%, suggesting that it contains only minimal impurities, making it a high-grade chemical compound.

InChI:InChI=1/C9H19NO3/c1-5-7(6-11)10-8(12)13-9(2,3)4/h7,11H,5-6H2,1-4H3,(H,10,12)/t7-/m0/s1

Upstream product

• 63658-16-2 (Z)-methyl 2-((tertbutoxycarbonyl)amino)but-2-enoate 
• 5856-62-2 (S)-2-aminobutan-1-ol 
• 34619-03-9 tert-butyldicarbonate 
• 121056-95-9 trimethyl 2-(tert-butoxycarbonylamino)phosphonoacetate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 251325-57-2 (1-hydroxymethyl-propenyl)-carbamic acid tert-butyl ester 
• 34306-42-8 Boc-Abu 

Downstream Products

• 153371-25-6 (2S)-2-(tert-butoxycarbonyl)aminobutyraldehyde 
• 911717-64-1 (1-{[(4-methoxy-phenyl)-(2-nitro-benzenesulfonyl)-amino]-methyl}-propyl)-carbamic acid tert-butyl ester 
• 13896-06-5 (S)-(-)-4-ethyl-2-oxazolidinone 
• 1598438-43-7 C₁₆H₂₃NO₄S 
• 251325-89-0 (S)-tert-butyl (1-aminobutan-2-yl)carbamate 
• 1297540-14-7 (S)-4-(1-(2-aminobutyl)-1H-pyrazol-3-yl)-2-chlorobenzonitrile 
• 1025065-72-8 (S)-2-(3-(3-(trifluoromethoxy)phenyl)imidazo[1,2-b]pyridazin-6-ylamino)butan-1-ol 
• 1025066-20-9 C₂₂H₂₅F₃N₄O₄ 
• 153371-26-7 (S)-2-(N-t-butoxycarbonylamino)-butyl cyanide 
• 757976-46-8 tert-butyl [(1S)-1-({[4-(benzyloxy)phenyl]amino}methyl)propyl]carbamate 
• 757976-19-5 tert-butyl ((1S)-1-{[(4-methoxyphenyl)amino]methyl}propyl)carbamate 
• 882296-91-5 (1-{[(4-benzyloxy-phenyl)-(2-nitro-benzenesulfonyl)-amino]-methyl}-propyl)-carbamic acid tert-butyl ester 
• 352704-76-8 (S)-N-Boc-2-aminobutanol tosylate 

Relevant articles and documents

Design, synthesis, and structure-activity relationship studies of L-amino alcohol derivatives as broad-spectrum antifungal agents

To discover broad spectrum antifungal agents, two strategies were applied, and a novel class of L-amino alcohol derivatives were designed and synthesized. 3-F substituted compounds 14i, 14n, 14s and 14v exhibited excellent antifungal activities with broad antifungal spectra against C. albicans and C. tropicalis, with MIC values in the range of 0.03–0.06 μg/mL, and against A. fumigatus and C. neoformans, with MIC values in the range of 1–2 μg/mL. Notably, Compounds 14i, 14n, 14s and 14v also displayed moderate activities against fluconazole-resistance strains 17# and CaR that were isolated from AIDS patients. Moreover, only compounds in the S-configuration showed antifungal activity. Preliminary mechanistic studies showed that the potent antifungal activity of compound 14v stemmed from inhibition of C. albicans CYP51. Compounds 14n and 14v were almost nontoxic to mammalian A549 cells, and their stability in human plasma was excellent.

Synthesis of vinyl sulfone-tethered proline derivatives as highly selective cathepsin s inhibitors

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Synthesis of proline analogues as potent and selective cathepsin S inhibitors

Cathepsin S is a potential target of autoimmune disease. A series of proline derived compounds were synthesized and evaluated as cathepsin S inhibitors. We discovered potent cathepsin S inhibitors through structure-activity relationship studies of proline analogues. In particular, compound 19-(S) showed promising in vitro/vivo pharmacological activities and properties as a selective cathepsin S inhibitor.