1507378-99-5Relevant articles and documents
Radical [3 + 2]-annulation of divinylcyclopropanes: Rapid synthesis of complex meloscine analogs
Zhang, Hanmo,Jeon, Kyu Ok,Hay, E. Ben,Geib, Steven J.,Curran, Dennis P.,Laporte, Matthew G.
, p. 94 - 97 (2014)
A radical [3 + 2]-divinylcyclopropane annulation cascade has been extended to encompass five D-ring variants of the meloscine/epimeloscine core structure. Representative ABCD tetracyclic intermediates were further elaborated with novel substituted E-rings through subsequent transformations of advanced intermediates that provided opportunities for late-stage variation of the B-ring (lactam) N-substituents which were also developed.