1507379-40-9Relevant academic research and scientific papers
Palladium-catalyzed α-arylation of benzylic phosphine oxides
Montel, Sonia,Jia, Tiezheng,Walsh, Patrick J.
supporting information, p. 130 - 133 (2014/01/23)
A novel approach to prepare diarylmethyl phosphine oxides from benzyl phosphine oxides via deprotonative cross-coupling processes (DCCP) is reported. The optimization of the reaction was guided by High-Throughput Experimentation (HTE) techniques. The Pd(OAc)2/Xantphos-based catalyst enabled the reaction between benzyl diphenyl or dicyclohexyl phosphine oxide derivatives and aryl bromides in good to excellent yields (51-91%).
