150748-86-0

Upstream product

• 100-17-4 para-methoxynitrobenzene 
• 925-90-6 ethylmagnesium bromide 
• 2386-64-3 ethylmagnesium chloride 
• 1826-67-1 vinyl magnesium bromide 
• 4433-63-0 Ethyl boronic acid 
• 98447-30-4 2-bromo-4-methoxy-1-nitrobenzene 
• 700-36-7 2-bromo-4-fluoronitrobenzene 

Downstream Products

• 114747-31-8 2-ethyl-4-methoxy-phenylamine 
• 1449669-17-3 (2-ethyl-4-methoxy-phenyl)-(1-methyl-1H-imidazo[4,5-c]pyridin-6-yl)amine 
• 1449665-09-1 N-(2-ethyl-4-methoxyphenyl)-N,1-dimethyl-1H-imidazo[4,5-c]pyridin-6-amine 

Relevant academic research and scientific papers

An indole derivative and its application

The present invention relates to an indole derivative shown in formula (I-1) and its use in the preparation of a drug for the prevention and / or treatment of indications associated with the S1P receptor disorders. Indole derivatives of the present invent

Discovery of a small molecule RXFP3/4 agonist that increases food intake in rats upon acute central administration

The relaxin family peptide receptors have been implicated in numerous physiological processes including energy homeostasis, cardiac function, wound healing, and reproductive function. Two family members, RXFP3 and RXFP4, are class A GPCRs with endogenous

IMIDAZO [4, 5 -C] PYRIDINE DERIVATIVES USEFUL FOR THE TREATMENT OF DEGENERATIVE AND INFLAMMATORY DISEASES

Wherein R1, L1, R3, R4, Cy, L2 and R5 are as defined herein. Novel imidazolopyridines according to Formula I, able to inhibit JAK are disclosed, these compounds may be prepared as a pharmaceutical composition, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, allergic or inflammatory conditions, autoimmune diseases, proliferative diseases, transplantation rejection, diseases involving impairment of cartilage turnover, congenital cartilage malformations, and/or diseases associated with hypersecretion of IL6 or interferons.

FUNGICIDAL 2-ALKYLTHIO-2-QUINOLINYLOXY-ACETAMIDE DERITVATIVES

Fungicidal compounds of the general formula (I), wherein the substituents are as defined in claim1.

Alkylation of nitroarenes with Grignard reagents via oxidative nucleophilic substitution of hydrogen

Alkylation of nitroarenes with Grignard reagents via oxidative nucleophilic substitution of hydrogen (ONSH) can be efficiently executed with potasium permanganate in liquid ammonia as an oxidative system for the σH adducts. The addition of RMgX to ArNO2 of stoichiometry 1:1 is accompanied with a redox process apparently of stoichiometry 2:1. Because of that, real stoichiometry of the reaction between nitroarenes and Grignard reagents is ca. 1:1.5.