150749-87-4

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• 15028-56-5 4-(benzyloxymethyl)-2,2-dimethyl-1,3-dioxolane 
• 100-44-7 benzyl chloride 
• 112-71-0 1-Bromotetradecane 
• 13071-59-5 3-benzyloxypropan-1,2-diol 
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• 1561-55-3 (±)-2,3-bis-tetradecyloxypropan-1-ol 

Relevant academic research and scientific papers

Synthesis and transfection properties of novel non-toxic monocationic lipids. Variation of lipid anchor, spacer and head group structure

This report describes the synthesis and the transfection properties of novel monocationic non-toxic lipids. We have carried out structural variations in all three units of the transfection lipid, the lipid anchor, the spacer moiety and the positively charged head group. Our results lead to the conclusion that systematic modification of structural subunits is a promising way to enhance the transfection efficiency. (C) 2000 Elsevier Science Ltd. All rights reserved.

Novel cationic amphiphiles

A cationic amphiphile for facilitating transport of a biologically active molecule into a cell has the structure A-F-D, in which A is a lipid anchor, D is a head group, and F is a spacer group having the structure described herein. A method for facilitating transport of a biologically active molecule into a cell comprises preparing a lipid mixture comprising a cationic amphiphile having structure A-F-D, preparing a lipoplex by contacting the lipid mixture with a biologically active molecule; and contacting the lipoplex with a cell, thereby facilitating transport of the biologically active molecule into the cell.

Langmuir-Blodgett film formation of succinic acid half-esters containing double long alkoxy chains

Two types of half-esters of succinic acid have been prepared. One contains a 1,2-dialkylated glyceryl group, while the other has a normal alkyl group as the hydrophobic group. The mono-molecular films of the half-esters developed at the air-water interface were evaluated by π-A curves. Multilayer Langmuir-Blodgett (L-B) films deposited on the substrate are discussed in terms of pinhole defects. Influences of the surface pressure on accumulation, the number of layers, and the chain length of the lipophilic group are analysed. The L-B film made from the double-chained homologues possessed fewer pinhole defects compared with that composed of the single-chained one.