150758-58-0Relevant academic research and scientific papers
SYNTHESIS OF N-ALKYL-1,2,4-OXADIAZINONES AS ANGIOTENSIN-II (AT1) RECEPTOR ANTAGONISTS
Weller, Harold N.,Miller, Arthur V.,Dickinson, Kenneth E.,Hedberg, S. Anders,Delaney, Carol L.,et al.
, p. 1027 - 1038 (2007/10/02)
4-Alkyl-1,2,4-oxadiazinones were prepared by regiospecific alkylation of the corresponding 4H-oxadiazinones, which were synthesized by a trimethylaluminium mediated cyclization reaction.Alkylation was regiospecyfic and generally facile; in one example, however, an unusual fragmentation reaction occurred.A homochiral oxadiazineone was also prepared and alkylated under the described conditions. 4-Biphenylmethyl-1,2,4-oxadi-azinones were potent angiotensin-II receptor antagonists.
