150798-78-0

Basic information

• Product Name: Benzoic acid, 4-[2-(dimethylamino)ethoxy]-
• Synonyms: Benzoic acid, 4-[2-(dimethylamino)ethoxy]-
• CAS NO: 150798-78-0
• Molecular Formula: C₁₁H₁₅NO₃
• Molecular Weight: 209
• Mol File: 150798-78-0.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 340℃
• Flash Point: 160℃
• Appearance: /
• Density: 1.145
• Storage Temp.: 2-8°C
• CAS DataBase Reference: Benzoic acid, 4-[2-(dimethylamino)ethoxy]-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 4-[2-(dimethylamino)ethoxy]-(150798-78-0)
• EPA Substance Registry System: Benzoic acid, 4-[2-(dimethylamino)ethoxy]-(150798-78-0)

Safety Data

• Hazardous Substances Data: 150798-78-0(Hazardous Substances Data)

Usage

General Description

Benzoic acid, 4-[2-(dimethylamino)ethoxy]- is a chemical compound that belongs to the class of benzoic acids. It is also known by its trade name, BDEE, and is commonly used as a reagent in organic synthesis. Benzoic acid, 4-[2-(dimethylamino)ethoxy]- is used as a starting material for the production of various pharmaceuticals, dyes, and fragrances, as well as in the manufacturing of polymers and plastics. It is also used as a preservative in food and beverages, as it exhibits antimicrobial properties. Additionally, it is used in the production of personal care products such as shampoos and soaps. The chemical structure of benzoic acid, 4-[2-(dimethylamino)ethoxy]- consists of a benzene ring with a carboxylic acid group attached to it, and an ethoxy group with a dimethylamino substituent.

Upstream product

• 120-47-8 Ethyl 4-hydroxybenzoate 
• 25773-00-6 ethyl 4-(dimethylaminoethoxy)benzoate 
• 99-76-3 methyl 4-hydroxylbenzoate 
• 73119-82-1 methyl 4-<2-(dimethylamino)ethoxy>benzoate 

Downstream Products

• 1338816-05-9 C₂₅H₃₁F₂N₃O₃ 

Relevant articles and documents

S1P1 AGONIST AND APPLICATION THEREOF

The present invention relates to a class of tricyclic compounds and an application thereof as a sphingosine 1-phosphate type 1 (S1P1) receptor agonist. The invention specifically relates to a compound represented by formula (II), and a tautomer and pharmaceutically acceptable salt of same.

Antiestrogens. 2. Structure-Activity Studies in a Series of 3-Aroyl-2-arylbenzothiophene Derivatives Leading to thien-3-yl>phenyl>methanone Hydrochloride (LY156758), a Remarkably Effective Estrogen Antagonist with On...

In an effort to prepare nonsteroidal antiestrogens demonstrating greater antagonism and less intrinsic estrogenicity than those currently available, a series of 3-aroyl-2-arylbenzothiophene derivatives was synthesized.These compounds were prepared by Friedel-Crafts aroylation of appropriate O-protected 2-arylbenzothiophene nuclei with basic side-chain-bearing benzoyl chlorides followed by removal of the protective groups to provide the desired compounds containing both hydroxyl and basic side-chain functionality.A particularly useful method for the cleavage of aryl methoxy ethers without removal of (dialkylamino)ethoxy side chain functionality elsewhere in the molecule was found to be AlCl3/EtSH.The benzothiophene derivatives were tested for their ability to inhibit the growth-stimulating action of estradiol on the immature rat uterus.Seemingly minor changes in the side-chain amine moiety were found to have profound effects on the ability of the compounds to antagonize estradiol.Analogues having basic side chains containing cyclic (pyrrolidine, piperidine, and hexamethyleneamine) moieties were found to have less intrinsic estrogenicity and to antagonize estradiol action more completely than their noncyclic counterparts.The most effective antiestrogen in the series, compound 44, thien-3-yl>phenyl>methanone, elicited a modest uterotropic activity that did not increase with increasing dose.In antagonism of estradiol, 44 exhibited a degree of inhibition surpassing that of tamoxifen at any dose tested.The new benzothiophene antiestrogen was also shown to have high affinity for rat uterine cycloplasmic estrogen receptor and to be an inhibitor of the growth of DMBA-induced rat mammary tumors.