150806-61-4

Basic information

• Product Name: 2-[N-[(2-methylpropan-2-yl)oxycarbonyl]anilino]acetic acid
• Synonyms: 2-[N-[(2-methylpropan-2-yl)oxycarbonyl]anilino]acetic acid;N-Boc-N-phenyl-glycine
• CAS NO: 150806-61-4
• Molecular Formula: C₁₃H₁₇NO₄
• Molecular Weight: 251.27838
• Mol File: 150806-61-4.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 382.6±25.0 °C(Predicted)
• Appearance: /
• Density: 1 +-.0.06 g/cm3(Predicted)
• PKA: 3.82±0.10(Predicted)
• CAS DataBase Reference: 2-[N-[(2-methylpropan-2-yl)oxycarbonyl]anilino]acetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[N-[(2-methylpropan-2-yl)oxycarbonyl]anilino]acetic acid(150806-61-4)
• EPA Substance Registry System: 2-[N-[(2-methylpropan-2-yl)oxycarbonyl]anilino]acetic acid(150806-61-4)

Safety Data

• Hazardous Substances Data: 150806-61-4(Hazardous Substances Data)

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 103-01-5 N-Phenylglycine 
• 2835-06-5 phenylglycin 
• 169268-95-5 tert-butyl allyl(phenyl)carbamate 
• 909114-65-4 tert-butyl 4,6-dimethoxy-1,3,5-triazinyl carbonate 

Downstream Products

• 185525-77-3 [1(R)-[(2,3-dihydrospiro[1H-indene-1,4'-piperidin]-1'-yl)carbonyl]-1-phenylmethyl]carbamic acid 1,1-dimethylethyl ester 
• 1224936-23-5 C₁₆H₁₉N₃O₃ 
• 1239914-06-7 C₂₄H₂₂N₂O₅ 
• 1056652-18-6 C₂₀H₂₅N₃O₅S 
• 769119-20-2 2-amino-2-phenyl-acetic acid octadec-(Z)-9-enyl ester 
• 179173-77-4 1-[[1-(N-Phenylamino)acetyl-4-piperidyl]methyl]-1H-2-methylimidazo[4,5-c]pyridine 

Relevant articles and documents

METHODS AND COMPOUNDS FOR RESTORING MUTANT p53 FUNCTION

Mutations in oncogenes and tumor suppressors contribute to the development and progression of cancer. The present disclosure describes compounds and methods to recover wild-type function to p53 mutants. The compounds of the present disclosure can bind to mutant p53 and restore the ability of the p53 mutant to bind DNA and activate downstream effectors involved in tumor suppression. The disclosed compounds can be used to reduce the progression of cancers that contain a p53 mutation.

1,2-NAPHTHOQUINONE DERIVATIVE AND METHOD FOR PREPARING SAME

Disclosed are a compound represented by Formula (1), or a pharmaceutically acceptable salt, hydrate, solvate, prodrug, tautomer, enantiomer, or pharmaceutically acceptable diastereomer thereof, a method of preparing the same, and a pharmaceutical composition, which have effects for treatment or prevention of metabolic syndromes, comprising the same: wherein R1to R6, X1 to X4, and n are the same as defined in Claim 1.

NOVEL COMPOUNDS

This invention relates to novel amide derivatives and salts thereof. More particularly, it relates to novel amide derivatives and salts thereof which act as a ROCK inhibitor, to a pharmaceutical composition comprising the same and to a method of using the same therapeutically in the treatment and/or prevention of ROCK-related disease.