15082-25-4Relevant academic research and scientific papers
Synthesis and Biological Activity of Some Schiff Bases Derived from Thiazoles and Benzothiazoles
Dash, B.,Patra, M.,Praharaj, S.
, p. 894 - 897 (2007/10/02)
4-Aryl-2-aminothiazoles and 2-aminobenzothiazoles undergo condensation with salicylaldehyde in the presence of piperidine to give the schiff bases II and III, respectively.A similar reaction of 4-aryl-2-aminothiazole methiodides gives the schiff bases 4-aryl-2-(2'-hydroxyaryliminomethyl)thiazole methiodides (IV).Several schiff bases have been condensed with cyclohexanone and thioglycollic acid to furnish 4-aryl-2-(2'-hydroxy-α-substituted benzylamino)thiazoles (V) and 2-(2'-hydroxyphenyl) or naphthyl)-3-(4''-arylthiazol-2''-yl)-4-thiazolidones (VI), respectively.Structure elucidation of the schiff bases has been made on the basis of their elemental analyses, IR and mass spectral data.The biological screening data of the schiff bases and their metal complexes are also presented.
