1508265-90-4Relevant academic research and scientific papers
Rapid, scalable assembly of stereochemically rich, mono- and bicyclic acyl sultams
Asad, Naeem,Samarakoon, Thiwanka B.,Zang, Qin,Loh, Joanna K.,Javed, Salim,Hanson, Paul R.
supporting information, p. 82 - 85 (2014/01/23)
A one-pot, sequential protocol is reported that involves complementary ambiphile pairing (CAP) of a vinyl sulfonamide with a variety of unprotected amino acids via aza-Michael addition and subsequent intramolecular amidation. The method generates diverse, sp3-rich mono- and bicyclic acyl sultams in a highly scalable manner. Modular pairing of stereochemically rich building blocks allows quick access to all possible isomers. Extension to include one-pot, sequential 3-, 4-, and 5-multicomponent protocols is also discussed.
