1508276-33-2Relevant academic research and scientific papers
Trans-bisglycoconjugation is an efficient and robust architecture for PDT photosensitizers based on 5,10,15,20-tetrakis(pentafluorophenyl)porphyrin derivatives
Hirohara, Shiho,Sharyo, Kohei,Kawasaki, Yuji,Totani, Masayasu,Tomotsuka, Ayumi,Funasako, Ryota,Yasui, Nobutaka,Hasegawa, Yasuchika,Yuasa, Junpei,Nakashima, Takuya,Kawai, Tsuyoshi,Oka, Chio,Kawaichi, Masashi,Obata, Makoto,Tanihara, Masao
supporting information, p. 1295 - 1308 (2014/01/06)
To examine the versatility of the trans-bisglycoconjugation architecture for 5,10,15,20-tetrakis(pentafluorophenyl) porphyrin (TFPP) derivative-based photodynamic therapy (PDT), 25 porphyrin derivatives bearing D-glucopyranose moieties were prepared, and their in vitro photocytotoxicities were examined. trans-Bisglycoconjugated TFPP derivatives exerted the best photocytotoxicity among TFPP derivatives in the same category, regardless of the central metal ion and the type of glycoconjugation. trans-Bisglycoconjugated free-base TFPP bearing β-D-glucopyranosylthio groups (trans- H22 SGlc) was found to be the most potent photosensitizer, not only in HeLa cells (EC50 50 a type I photoreaction, while no significant differences were found in the efficiency of singlet oxygen generation by a type II photoreaction. These unique characteristics of transbisglycoconjugated TFPP derivatives support the conclusion that trans-bisglycoconjugation is a highly efficient and robust architecture for TFPP-based PDT development.
