1508278-82-7

Basic information

• Product Name: C₂₅H₄₅NO₄SSi
• Synonyms: C₂₅H₄₅NO₄SSi
• CAS NO: 1508278-82-7
• Molecular Weight: 483.788
• Mol File: 1508278-82-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₅H₄₅NO₄SSi(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₅H₄₅NO₄SSi(1508278-82-7)
• EPA Substance Registry System: C₂₅H₄₅NO₄SSi(1508278-82-7)

Safety Data

• Hazardous Substances Data: 1508278-82-7(Hazardous Substances Data)

Upstream product

• 852447-17-7 tert-butyl 2-(tert-butyldimethylsilyl)-2-oxoacetate 
• 100-58-3 phenylmagnesium bromide 
• 221375-47-9 (R)-(-)-N-(propylidene)-2-methylpropane-2-sulfinamide 

Relevant articles and documents

Efficient synthesis of α-quaternary α-hydroxy-β-amino esters via silyl glyoxylate-mediated three-component reactions

An efficient method has been developed for the enantioselective synthesis of fully protected α-quaternary α-hydroxy-β-amino esters via the coupling of three components: aryl Grignard reagents (or methyllithium), silyl glyoxylate, and N-tert-butanesulfinyl imines. This protocol enables successive formation of two C-C bonds and two adjacent chiral carbons with high stereocontrol in a one-pot operation.