150869-54-8Relevant articles and documents
Process for the preparation of tetrazoles
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, (2008/06/13)
The present invention relates to a process for the preparation of 5-aryl tetrazoles of the formula: STR1 or a salt thereof comprising reacting an aryl nitrile with a trisubstituted silyl azide and a disubstituted tin oxide.
1,3-oxazolyl substituted biphenyl
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, (2008/06/13)
The present invention relates to a process for the preparation of a compound of the formula: STR1 wherein R1 is selected from the group consisting of hydrogen, loweralkyl, loweralkoxy-substituted loweralkyl, lower alkenyl, lower alkynyl, cycloalkyl and cycloalkylalkyl; R2 is selected from the group consisting of hydrogen, loweralkyl, loweralkoxy-substituted loweralkyl, halogen and loweralkoxy; R3 is selected from hydrogen, loweralkyl, and halogen; R* and R** are independently selected from loweralkyl and P1 is hydrogen or an nitrogen-protecting group; or an acid addition salt thereof.
An efficient synthesis of an angiotensin II antagonist (A-81988)
Kerdesky,Haight,Narayanan,Nordeen,Scarpetti,Seif,Wittenberger,Morton
, p. 2027 - 2039 (2007/10/02)
A new and efficient synthesis of A-81988, an angiotensin II antagonist, is described. The preparation utilizes a novel method for tetrazole formation from nitriles requiring trimethylsilyl azide and a catalytic amount of dialkyltin oxide.