150880-89-0Relevant academic research and scientific papers
New synthesis of (Z)-and (E)-3-styryl-4-quinolones
Seixas, Raquel S. G. R.,Silva, Artur M. S.,Cavaleiro, José A. S.
experimental part, p. 2257 - 2262 (2010/11/04)
A novel and efficient route for the synthesis of (Z)-and (E)-3-styryl-4-quinolones is described. Wittig reaction of 4-(chloroquinoline- and quinolone)-3-carbaldehydes with benzylic ylides is the key transformation for this synthetic route. The (Z)-1-methyl-3-styryl-4-quinolone is obtained with high diastereoselectivity from the reaction of 1-methyl-4-quinolone-3- carbaldehyde; while (E)-3-styryl-4-quinolone is prepared through the Wittig reaction of 4-chloroquinoline-3-carbaldehyde followed by acid hydrolysis. Both synthetic routes are efficient regardless of the substituents on the benzylic ylides. Georg Thieme Verlag Stuttgart - New York.
Wittig reactions of chromone-3-carboxaldehydes with benzylidenetriphenyl phosphoranes: A new synthesis of 3-styrylchromones
Sandulache, Angela,Silva, Artur M. S.,Pinto, Diana C. G. A.,Almeida, Lucia M. P. M.,Cavaleiro, Jose A. S.
, p. 1592 - 1598 (2007/10/03)
An efficient route to 3-styrylchromones has been developed and applied to syntheses of several new derivatives. Wittig reactions of chromone-3- carboxaldehydes with some benzylic ylides gave a diastereomeric mixture of (E) and (Z)-3-styrylchromones that a
