150900-91-7Relevant academic research and scientific papers
HYDANTOIN DERIVATES AS KV3 INHIBITORS
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Page/Page column 58, (2013/02/27)
The invention provides compounds of formula (I): Said compounds being inhibitors of Kv3 channels and of use in the prophylaxis or treatment of related disorders.
Avoiding the classical resolution during the synthesis of MeO-BIPHEP and 3,3′-disubstituted derivatives
Gorobets, Evgueni,Wheatley, Bronwen M. M.,Hopkins, J. Matthew,McDonald, Robert,Keay, Brian A.
, p. 3843 - 3846 (2007/10/03)
The Ullmann coupling of 1 (R = H) gives a 2:1 mixture of diastereomers 2 (R = H) in 81% yield that are easily separated by silica gel chromatography. This procedure avoids the generally cumbersome and sometimes difficult resolution step with DBTA. Similar Ullmann couplings and separation of the corresponding diastereomers are employed with other derivatives of 1 (R = OtBu, iPr, Ph, and mesityl) ultimately affording a new series of 3,3′-disubsituted-MeO-BIPHEP derivatives. The use of these new derivatives in palladium-catalyzed asymmetric Heck reaction, Pd-catalyzed polyene cyclizations and rhodium-catalyzed hydrogenations is also reported.
