15093-14-8 Usage
Uses
Used in Pharmaceutical Industry:
18-Nor-17β-estradiol is used as a pharmaceutical intermediate for the development of selectively active estrogens. Its application is based on its ability to interact specifically with the estrogen-receptor in human breast carcinoma cells, which can potentially lead to the development of targeted therapies for breast cancer.
Used in Research and Development:
In the field of research and development, 18-Nor-17β-estradiol serves as a valuable tool for studying the mechanisms of estrogen action and its role in various physiological processes. This knowledge can be applied to develop new drugs and therapies for conditions related to estrogen imbalance or deficiency.
Used in Hormone Replacement Therapy:
18-Nor-17β-estradiol may also be used as a component in hormone replacement therapy, particularly for postmenopausal women. Its selective activity on estrogen receptors could potentially offer targeted relief from menopausal symptoms while minimizing the risk of side effects associated with non-selective estrogens.
Used in Endocrine Disruption Studies:
As a novel intermediate of Estradiol, 18-Nor-17β-estradiol can be utilized in endocrine disruption studies to understand the impact of environmental chemicals on hormonal balance and reproductive health. This application can contribute to the development of strategies to mitigate the effects of endocrine-disrupting chemicals on human health and the environment.
Check Digit Verification of cas no
The CAS Registry Mumber 15093-14-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,5,0,9 and 3 respectively; the second part has 2 digits, 1 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 15093-14:
(7*1)+(6*5)+(5*0)+(4*9)+(3*3)+(2*1)+(1*4)=88
88 % 10 = 8
So 15093-14-8 is a valid CAS Registry Number.
15093-14-8Relevant academic research and scientific papers
Kuhl, Alexander,Karels, Heiko,Kreiser, Wolfgang
, p. 30 - 34 (1999)
The partial synthesis of 18-norestradiol (1) via Wittig-Schollkopf cyclization of an appropriately functionalized D-seco-steroid 9, obtained in nine steps from estrone, (2) is described. The crucial hydration of the C(13)=C(17) bond in an anti-Markovnikov
