150935-70-9Relevant academic research and scientific papers
Synthesis of Mannose 6-Phosphate-containing Disaccharide Threonine Building Blocks and their Use in Solid-phase Glycopeptide Synthesis
Christensen, Mette K.,Meldal, Morten,Bock, Klaus
, p. 1453 - 1460 (2007/10/02)
The preparation of 6'-O-phosphorylated α(1,2)- and α(1,6)-linked mannose disaccharides is described, starting from phenyl 2,3,4-tri-O-benzoyl-1-thio-α-D-mannopyranoside and using bis-(2,2,2-trichloroethyl)phosphorochloridate as phosphorylating reagent.The mannobiosides were converted into glycosyl donors and used in glycosylations of Nα-Fmoc-Thr-OPfp.The resulting glycosylated building blocks, 11 and 12, were used in solid-phase glycopeptide synthesis of O-mannosylated tripeptides.
