150969-30-5Relevant articles and documents
Synthesis of α-galactosyl ceramide, a potent immunostimulatory agent
Plettenburg, Oliver,Bodmer-Narkevitch, Vera,Wong, Chi-Huey
, p. 4559 - 4564 (2007/10/03)
α-Galactosyl ceramide has been identified to be a potent stimulatory agent for a novel immunological process, mediated by CD1 molecules. This paper describes a short and efficient synthesis of α-galactosyl ceramide. Starting from commercially available 2-deoxy galactose, a suitable sphingosine derivative was obtained in nine steps and 36% overall yield, which was subsequently glycosylated to give the target molecule. This flexible route will provide various glycolipids for further exploration of this interesting biological process.
Synthesis of structural elements of the capsular polysaccharide of Streptococcus pneumoniae type 8
Koeman,Kamerling,Vliegenthart
, p. 5291 - 5304 (2007/10/02)
The synthesis is reported of propyl 4-O-α-D-galactopyranosyl-β-D-glucopyranosiduronic acid (25), 4-O-[4-O-(β-D-glucopyranosyluronic acid)-β-D-glucopyranosyl]-D-glucopyranose (34) and 4-O-(4-O-β-D-glucopyranosyl-α-D-glucopyranosyl)-D-galactopyranose (38),