15097-72-0Relevant academic research and scientific papers
A Modular Synthesis of 2-Alkyl- and 2-Arylchromans via a Three-Step Sequence
Orr, Robert K.,Campeau, Louis-Charles,Chobanian, Harry R.,McCabe Dunn, Jamie M.,Pio, Barbara,Plummer, Christopher W.,Nolting, Andrew,Ruck, Rebecca T.
, p. 657 - 666 (2017/01/28)
A convergent three-step method for the synthesis of 2-substituted chromans is described. These results have been accomplished via the Heck coupling of readily accessible allylic alcohols and 2-iodophenols, followed by reduction and Mitsunobu cyclization. The utility and generality of this method is demonstrated through the synthesis of a series of 2-aryl-, 2-heteroaryl- and 2-alkylchromans, as well as an azachroman derivative. The asymmetric version of this approach via a Noyori-catalyzed ketone reduction and subsequent cyclization is likewise highlighted.
