150993-19-4Relevant academic research and scientific papers
Researches on antiviral agents. 3. Synthesis and transformations of racemic and chiral 6-oxiranyl pyrimidinones
Botta, Maurizio,Saladino, Raffaele,Lamba, Doriano,Nicoletti, Rosario
, p. 6053 - 6070 (2007/10/02)
The synthesis of epoxides 3, 4 and 6 has been described. The transformation of 3 into C-6 alkylated uracils 22a-e, 23a-d, 24 and 25 is also reported. The chiral epoxide (S)-(+)-3 has been prepared via a modified Solladie procedure, while the ZnCl2- DIBAH reduction step failed to give the expected enantiomer (R)-(-)-3. This result has been discussed on the ground of molecular modeling studies.
