15100-06-8Relevant academic research and scientific papers
Cellulose sulfuric acid as a bio-supported and efficient solid acid catalyst for synthesis of pyrazoles in aqueous medium
Nasseri, Mohammad Ali,Salimi, Mehri,Esmaeili, Abbas Ali
, p. 61193 - 61199 (2014)
A convenient and practical method was described for the regioselective synthesis of pyrazoles from hydrazines/hydrazides and 1,3-dicarbonyl compounds via the Knorr synthesis in water with cellulose sulfuric acid (CSA) as a biopolymer-based solid acid catalyst. Various hydrazines and hydrazides were reacted with 1,3 diketones and the desired pyrazoles were obtained in high yields. The reaction of less reactive hydrazines with 1,3-dicarbonyl compounds stopped at the corresponding hydrazone derivatives. Hydrazides were employed with β-ketoester, and imine adducts were the only isolated product. Simple isolation of products, mild reaction conditions, reusability of solid acid catalysts and short reaction times are advantages of this green procedure. This journal is
Application of Fe3O4@SiO2@sulfamic acid magnetic nanoparticles as recyclable heterogeneous catalyst for the synthesis of imine and pyrazole derivatives in aqueous medium
Zakerinasab,Nasseri,Hassani,Samieadel
, p. 3169 - 3181 (2016/04/05)
Sulfamic acid supported on Fe3O4@SiO2 superpara magnetic nanoparticles was successfully applied as a recyclable solid acid catalyst with a large density of sulfamic acid groups for the synthesis of pyrazole derivatives, an important class of potentially bioactive compounds. The products are obtained in high yield from the one-pot reaction procedure involving dicarbonyl compounds and hydrazines/hydrazides. This new method totally avoids the use of toxic or expensive solvents and organic acids in this reaction.
PEG-SO3H as a mild, efficient and green catalytic system for the synthesis of pyrazole derivatives in aqueous medium
Nasseri,Alavi,Zakeri Nasab
, p. 213 - 219 (2013/07/26)
A versatile, alternative and environmentally benign strategy for the synthesis of a series of pyrazoles has been successfully performed in water using PEG-SO3H as an acidic catalyst. The products are obtained in high yield from the one-pot reaction procedure involving dicarbonyl compounds and hydrazines/hydrazides. This new method totally avoids the use of organic acids and toxic or expensive solvents in this reaction. The catalyst is waste-free, easily prepared, and efficiently re-used.
