151049-87-5

Basic information

• Product Name: 1H-Pyrazole,3-bromo-1-methyl-(9CI)
• Synonyms: 3-BroMo-1-Methyl-1H-pyraz...;1-Methyl-3-bromopyrazole;1H-Pyrazole,3-bromo-1-methyl-(9CI);1H-Pyrazole, 3-bromo-1-methyl;3-Bromo-1-methylpyrazole;3-Bromo-1-methyl-1H-pyrazole
• CAS NO: 151049-87-5
• Molecular Formula: C₄H₅BrN₂
• Molecular Weight: 161.01
• Product Categories: Building Blocks;Pyrazole;Heterocycles;HALIDE
• Mol File: 151049-87-5.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 197.064 °C at 760 mmHg
• Flash Point: 106℃
• Appearance: /
• Density: 1.585 g/mL at 25 °C
• Vapor Pressure: 0.543mmHg at 25°C
• Refractive Index: n20/D1.528
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: -0.27±0.10(Predicted)
• CAS DataBase Reference: 1H-Pyrazole,3-bromo-1-methyl-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrazole,3-bromo-1-methyl-(9CI)(151049-87-5)
• EPA Substance Registry System: 1H-Pyrazole,3-bromo-1-methyl-(9CI)(151049-87-5)

Safety Data

• RIDADR: UN 2811 6.1 / PGIII
• WGK Germany: 3
• Hazardous Substances Data: 151049-87-5(Hazardous Substances Data)

Usage

General Description

1H-Pyrazole, 3-bromo-1-methyl-(9CI) is a chemical compound with the molecular formula C4H6BrN2 and a molecular weight of 154.007 g/mol. It is a derivative of pyrazole, which is a heterocyclic aromatic organic compound. This chemical is characterized by the presence of a bromine atom and a methyl group attached to the pyrazole ring. It is commonly used in the field of organic synthesis and pharmaceutical research as a building block for the synthesis of more complex compounds with potential biological activities. Additionally, the presence of the bromine atom makes it useful in various chemical reactions as a halogenation reagent. 1H-Pyrazole,3-bromo-1-methyl-(9CI) is also a useful intermediate in the production of agrochemicals and other fine chemicals.

InChI:InChI=1/C4H5BrN2/c1-7-3-2-4(5)6-7/h2-3H,1H3

Upstream product

• 1904-31-0 methyl-1 amino-3 pyrazole 

Downstream Products

• 151049-89-7 1-(1-methyl-3-pyrazolyl)phenylmethanol 
• 92525-20-7 (1-methyl-1H-pyrazol-3-yl)(phenyl)methanone 
• 60031-47-2 1-(1-methyl-1H-pyrazol-3-yl)ethanol 
• 162435-06-5 1-methyl-3-(pyridin-2-yl)-1H-pyrazole 
• 73387-57-2 3-(4-methoxyphenyl)-1-methyl-1H-pyrazole 
• 1020174-04-2 1-methyl-3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-pyrazole 
• 2090743-53-4 3-bromo-4-fluoro-1-methyl-1H-pyrazole 

Relevant articles and documents

Strategy to Prepare 3-Bromo- and 3-Chloropyrazoles

A general strategy to prepare substituted 3-bromo- and 3-chloropyrazoles is described. The three-step method involves condensation of crotonates or β-chloro carboxylic acids with hydrazines, followed by halogenation and oxidation. Several condensation and oxidation protocols were developed to enable preparation of a wide variety of 3-halopyrazoles with good to excellent yields and regiocontrol.

HETEROCYCLIC COMPOUND

The present invention provides an agent for the prophylaxis or treatment of autoimmune diseases (e.g., psoriasis, rheumatoid arthritis, inflammatory bowel disease, Sjogren's syndrome, Behcet's disease, multiple sclerosis, systemic lupus erythematosus etc.) and the like, which has a superior Tyk2 inhibitory action. The present invention relates to a compound represented by the formula wherein each symbol is as defined in the specification, or a salt thereof.