151052-34-5

Basic information

• Product Name: 5-[4'-(DibroMoMethyl)[1,1'-biphenyl]-2-yl]-2-(triphenylMethyl)-2H-tetrazole
• Synonyms: 5-[4'-(DibroMoMethyl)[1,1'-biphenyl]-2-yl]-2-(triphenylMethyl)-2H-tetrazole
• CAS NO: 151052-34-5
• Molecular Formula: C33H24Br2N4
• Molecular Weight: 636.37846
• Product Categories: Amines, Aromatics, Heterocycles, Impurities, Intermediates, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 151052-34-5.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 738.3±70.0 °C(Predicted)
• Appearance: /
• Density: 1.42±0.1 g/cm3(Predicted)
• PKA: -0.10±0.12(Predicted)
• CAS DataBase Reference: 5-[4'-(DibroMoMethyl)[1,1'-biphenyl]-2-yl]-2-(triphenylMethyl)-2H-tetrazole(CAS DataBase Reference)
• NIST Chemistry Reference: 5-[4'-(DibroMoMethyl)[1,1'-biphenyl]-2-yl]-2-(triphenylMethyl)-2H-tetrazole(151052-34-5)
• EPA Substance Registry System: 5-[4'-(DibroMoMethyl)[1,1'-biphenyl]-2-yl]-2-(triphenylMethyl)-2H-tetrazole(151052-34-5)

Safety Data

• Hazardous Substances Data: 151052-34-5(Hazardous Substances Data)

Usage

Uses

5-[4'-(Dibromomethyl)[1,1'-biphenyl]-2-yl]-1-(triphenylmethyl)-1H-tetrazole is an impurity of 5-(4'-Bromomethyl-biphenyl-2-yl)-1-trityl-1h-tetrazole, an intermediate in the synthesis of Losartan (L470500) and Valsartan (V095750).

Relevant articles and documents

2-(tetrazol-5-yl)-1,1'-biphenyl derivatives, their preparation and their use as synthetic intermediates

Compounds corresponding to the formula (I) STR1 in which X represents dibromomethyl, formyl, (C1-4)alkyl, or a group CH(OR5)2 or CH(OH)OR5, wherein the or each R5 is hydrogen (C1-3)alkyl or the two R5 's in the case of CH(OR5)2 are linked to provide a 1,3-dioxolane or 1,3-dioxane ring, and Y represents hydrogen, 1,1-dimethylethyl, triphenylmethyl, trimethylstannyl, tributylstannyl, (1,1-dimethylethyl)dimethylsilyl, (1,1-dimethylethyl)diphenylsilyl, 2-cyanoethyl, or a group CH2 OR6 wherein R6 is methyl, phenylmethyl, 1,1-dimethylethyl, 2,2,2-trichloroethyl, benzyloxycarbonyl or 2,2,2-trichloroethyloxycarbonyl, Y being in position 1 or 2 on the tetrazole ring. The compounds of formula (I) are useful as intermediates in the synthesis of compounds possessing therapeutic activity.