1510796-70-9

Upstream product

• 321-69-7 5-fluoroisatoic anhydride 
• 1510796-66-3 6-fluoro-1-methyl-2-(5-(2-methylthiazol-4-yl)thiophen-2-yl)-3-phenyl-2,3-dihydroquinazolin-4(1H)-one 
• 61352-46-3 6-fluoro-1-methyl-2H-benzo[d][1,3]oxazine-2,4(1H)-dione 
• 446-08-2 2-amino-5-fluorobenzoic acid 

Relevant academic research and scientific papers

(S)-N-methyldihydroquinazolinones are the active enantiomers of retro-2 derived compounds against toxins

This study reports the synthesis, chromatographic separation, and pharmacological evaluation of the two enantiomers of a new compound, named Retro-2.1, active against toxins by inhibiting intracellular trafficking via the retrograde route. The absolute configuration of the bioactive enantiomer has been assigned from X-ray diffraction to the (S)-enantiomer. To date, (S)-Retro-2.1 is the most potent molecule to counteract the cytotoxic potential of ricin and Shiga toxin, with EC50 values of 23 and 54 nM, respectively.