1510867-00-1Relevant articles and documents
Commercial manufacturing of propofol: Simplifying the isolation process and control on related substances
Pramanik, Chinmoy,Kotharkar, Sandeep,Patil, Pradip,Gotrane, Dinkar,More, Yogesh,Borhade, Ajit,Chaugule, Balaji,Khaladkar, Tushar,Neelakandan,Chaudhari, Ashok,Kulkarni, Mukund G.,Tripathy, Narendra K.,Gurjar, Mukund K.
, p. 152 - 156 (2014/05/20)
A commercially viable manufacturing process for propofol (1) is described. The process avoids acid-base neutralization events during isolation of intermediate, 2,6-di-isopropylbenzoic acid (3) and crude propofol, and thus simplifies the synthesis on industrial scale to a considerable extent. Syntheses of five impurities/related substances (USP and EP) are also described.
