15109-94-1

Basic information

• Product Name: 2-BROMO-1-(2-FURYL)-1-ETHANONE
• Synonyms: TIMTEC-BB SBB010227;BUTTPARK 147\06-34;2-(2-BROMOACETYL)FURAN;2-BROMO-1-(2-FURYL)-1-ETHANONE;2-BROMO-1-FURAN-2-YL-ETHANONE;2-bromo-1-(2-furyl)ethanone;2-(alpha-Bromoacetyl)furan;2-Bromo-1-(2-furanyl)ethanone
• CAS NO: 15109-94-1
• Molecular Formula: C₆H₅BrO₂
• Molecular Weight: 189.01
• Product Categories: Acetyl Halides;Furans, Benzofurans & Dihydrobenzofurans;Acetyl Halides;Furans, Benzofurans & Dihydrobenzofurans
• Mol File: 15109-94-1.mol
• Article Data: 66

Chemical Properties

• Melting Point: 34 °C
• Boiling Point: 227℃
• Flash Point: 91℃
• Appearance: /
• Density: 1.616
• Vapor Pressure: 0.0815mmHg at 25°C
• Refractive Index: 1.533
• Storage Temp.: Sealed in dry,Store in freezer, under -20°C
• CAS DataBase Reference: 2-BROMO-1-(2-FURYL)-1-ETHANONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-BROMO-1-(2-FURYL)-1-ETHANONE(15109-94-1)
• EPA Substance Registry System: 2-BROMO-1-(2-FURYL)-1-ETHANONE(15109-94-1)

Safety Data

• Hazard Codes: Xi,C
• Statements: 22-34-43
• Safety Statements: 26-36/37/39-45
• RIDADR: UN 3261 8/PG 2
• HazardClass: IRRITANT
• Hazardous Substances Data: 15109-94-1(Hazardous Substances Data)

Usage

Uses

2-Bromo-1-furan-2-yl-ethanone is a reagent that is used in the preparation of diaryldihydropyrrolizine derivatives and their activity as cyclooxygenase and lipoxygenase inhibitors.

InChI:InChI=1/C6H5BrO2/c7-4-5(8)6-2-1-3-9-6/h1-3H,4H2

Upstream product

• 186581-53-3 diazomethane 
• 527-69-5 2-furancarbonyl chloride 
• 110-00-9 furan 
• 598-21-0 2-Bromoacetyl bromide 
• 1192-62-7 1-(2-furyl)-1-ethanone 
• 62889-08-1 1-(2-furyl)-1-(trimethylsilyloxy)ethylene 
• 614-99-3 Ethyl 2-furoate 
• 74-95-3 1,1-dibromomethane 
• 109988-03-6 2-furyl (trimethylsilyl)methyl ketone 
• 60-29-7 diethyl ether 
• 21443-46-9 2-diazoacetylfuran 
• 18649-64-4 2-ethynylfuran 
• 615-08-7 2-furoic anhydride 

Downstream Products

• 88-14-2 2-furanoic acid 
• 17678-19-2 2-(2-hydroxyacetyl)furan 
• 28795-36-0 2-(furan-2-yl)imidazo[1,2-a]pyridine 
• 31877-31-3 ethyl 4-(2-furyl)thiazol-2-carboxylate 
• 64493-95-4 6-furan-2-yl-3-(4-methoxy-phenyl)-[1,2,4]triazine 
• 64541-65-7 6-furan-2-yl-3-phenyl-[1,2,4]triazine 
• 64493-96-5 6-furan-2-yl-3-(3,4,5-trimethoxy-phenyl)-[1,2,4]triazine 
• 21036-72-6 4-furan-2-yl-2-p-tolyl-1⁽³⁾H-imidazole 
• 28989-52-8 2-amino-4-(2-furyl)thiazole 
• 21036-69-1 4-furan-2-yl-2-phenyl-1⁽³⁾H-imidazole 
• 21036-63-5 4-(2-furyl)-2-phenylthiazole 
• 64493-94-3 6-furan-2-yl-3-p-tolyl-[1,2,4]triazine 
• 21036-71-5 2-(4-chloro-phenyl)-4-furan-2-yl-1⁽³⁾H-imidazole 
• 66442-83-9 (furyl-2)-2 imidazo<1,2-a>pyrimidine 

Relevant articles and documents

Asymmetric synthesis of 7-aza-phomopsolide E and its C-4 epimer

A flexible, enantioselective route to highly functionalized α,β-unsaturated δ-lactones has been applied to the synthesis of 7-aza-phomopsolide E and its C-4 epimer. This approach relies on the application of the Noyori asymmetric hydrogenation of furyl ketone to produce the secondary furyl alcohol in high enantioexcess, which can be stereoselectively transformed into α,β-unsaturated-δ-lactones by a short, highly diastereoselective oxidation and reduction sequence. DCC and acid chloride couplings were used to introduce the side chains of the two natural product analogues.

Based on isoxazole substitution of benzamide derivatives and anti-prostate cancer drug applications

The present invention discloses a class (I), formula (II) structure based on isoxazole substituted benzamide derivatives and antiprostate cancer drug applications, such isoxazole substituted benzamide derivatives, can effectively inhibit the activity of a

Base-Catalyzed Intramolecular Defluorination/O-Arylation Reaction for the Synthesis of 3-Fluoro-1,4-oxathiine 4,4-Dioxide

A novel process involving base-catalyzed intramolecular defluorination/O-arylation of readily available α-fluoro-β-one-sulfones was realized and provided a series of 3-fluoro-1,4-oxathiine 4,4-dioxide derivatives in good to excellent yields. Unlike traditional defluorination reactions with stoichiometric base as the deacid reagent, this process is triggered by a catalytic amount of base (TMG: tetramethylguanidine) and molecular sieves serve as both an adsorbent to remove HF acid and an activator to assist C-F bond cleavage.

Oxidation Potential-Guided Electrochemical Radical-Radical Cross-Coupling Approaches to 3-Sulfonylated Imidazopyridines and Indolizines

Oxidation potential-guided electrochemical radical-radical cross-coupling reactions between N-heteroarenes and sodium sulfinates have been established. Thus, simple cyclic voltammetry measurement of substrates predicts the likelihood of successful radical-radical coupling reactions, allowing the simple and direct synthetic access to 3-sulfonylated imidazopyridines and indolizines. The developed electrochemical radical-radical cross-coupling reactions to sulfonylated N-heteroarenes boast the green synthetic nature of the reactions that are oxidant- and metal-free.