151126-32-8 Usage
Uses
Antidiabetic.
Enzyme inhibitor
This 37-residue pancreatic β-cell hormone (MW = 3.9 kDa; Sequence:
KCNTATCATQRLANFLVHSSNNFGAILSSTNVGSNTY), also called
Islet Amyloid Polypeptide (IAPP), is co-secreted with insulin and plays a
role in glycemic regulation by retarding gastric emptying and promoting
satiety. Amylin helps to prevent post-prandial spikes in blood glucose.
Amylin potently inhibits (EC50 = 18 pM) amino acid-stimulated glucagon
secretion. (Note: Human amylin is amyloidogenic, whereas the synthetic
hormone known as Pramlintide (MW = 3951.41g; CAS 151126-32-8;
Sequence: KCNTATCATQRLANFLVHSSNNFGPILPPTNVGSNTY-NH2;
Tradename: Symlin?) contains three prolyl residues that are found in Rat
Amylin (Sequence: KCNTATCATQRLANFLVRSSNNLGPVLPPTNG
SNTY) and is nonamyloidogenic.)
Check Digit Verification of cas no
The CAS Registry Mumber 151126-32-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,1,1,2 and 6 respectively; the second part has 2 digits, 3 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 151126-32:
(8*1)+(7*5)+(6*1)+(5*1)+(4*2)+(3*6)+(2*3)+(1*2)=88
88 % 10 = 8
So 151126-32-8 is a valid CAS Registry Number.
InChI:InChI=1/C171H269N51O53S2/c1-21-81(12)130(163(268)207-110(56-78(6)7)169(274)222-53-33-42-118(222)170(275)221-52-32-41-117(221)160(265)219-135(89(20)230)167(272)206-109(66-125(180)238)151(256)212-128(79(8)9)161(266)186-68-126(239)192-111(70-223)154(259)203-107(64-123(178)236)152(257)218-134(88(19)229)166(271)195-98(136(181)241)57-92-43-45-94(231)46-44-92)214-159(264)116-40-31-51-220(116)127(240)69-187-141(246)101(58-90-34-24-22-25-35-90)199-148(253)105(62-121(176)234)201-149(254)106(63-122(177)235)202-155(260)112(71-224)209-156(261)113(72-225)208-146(251)103(60-93-67-184-75-188-93)205-162(267)129(80(10)11)213-150(255)100(55-77(4)5)198-145(250)102(59-91-36-26-23-27-37-91)200-147(252)104(61-120(175)233)196-137(242)82(13)189-144(249)99(54-76(2)3)197-142(247)96(39-30-50-185-171(182)183)193-143(248)97(47-48-119(174)232)194-165(270)132(86(17)227)215-138(243)83(14)190-157(262)114(73-276)211-168(273)133(87(18)228)216-139(244)84(15)191-164(269)131(85(16)226)217-153(258)108(65-124(179)237)204-158(263)115(74-277)210-140(2