151135-94-3Relevant academic research and scientific papers
Synthesis, Crystal Structure, Biological Evaluation, DFT Calculations and Third Order Nonlinear Optical Studies of Pyrazolines
Gaonkar, Santosh L.,Hari, Gangadhar,Lokanath, N. K.,Naraharisetty, Sri Ram G,Nayak, Swarnagowri,Pai, K. S. R.,Parol, Vinay,Sinha, Rajeev K.
, (2021/06/15)
Novel pyrazoline derivatives were synthesized and characterized by FTIR, NMR, UV-visible, and mass spectral studies. All the synthesized compounds 6a-f were screened for anticancer activity against MCF-7 and HCT 116 cell lines via SRB assay. Among the synthesized pyrazolines 6b and 6f showed appreciable anticancer activity. The molecular docking study was done with two proteins (PDB No: 1M17 and 5ZTO) to study the binding interactions of the compounds with proteins. ADME study showed that the compounds exhibited drug-likeness properties, following Lipinski's rule of five. The molecular structure of compound 6b was studied using the single-crystal X-ray diffraction method. The structural, absorption and first static hyperpolarizability properties of the compound 6b were studied using density functional theory (DFT) calculations. The experimental data and calculated FTIR and UV-visible spectral data are in good agreement. The third order nonlinear optical properties were studied using open and closed aperture z-scan techniques. The compound 6b showed nonlinear absorption(β) of 1.94×10?11m/W at intensity (I0) is 4.49GW/cm2. Third order nonlinear susceptibility is of the order of 10?12 esu and this indicates the molecule has the potential to be used in nonlinear optical device applications.
New class of hybrids based on chalcone and melatonin: a promising therapeutic option for the treatment of colorectal cancer
Arias, Juan D.,Cardona-G, Wilson,Herrera-R, Angie,Moreno, Gustavo,Yepes, Andrés F.
, p. 2240 - 2255 (2021/10/20)
Considering that conventional chemotherapy provides only a limited increase of overall survival for patients with colorectal cancer (CRC), and resistance is a major cause of therapeutic failure, the emergence of new therapies is needed. Development of dif
Anti-tumor activity of new artemisinin-chalcone hybrids
Xie, Lijun,Zhai, Xin,Liu, Chun,Li, Peng,Li, Yangxiong,Guo, Guoxian,Gong, Ping
experimental part, p. 639 - 647 (2012/06/29)
In an attempt to develop potent and selective anti-tumor agents, three new series of artemisinin-chalcone hybrids 10a-10g, 11a-11g and 12a-12h were designed, synthesized and screened for their anti-tumor activity against five cell lines (HT-29, A549, MDA-MB-231, HeLa and H460) in vitro. Among compounds 10a-g and 11a-11g, most of them displayed enhanced activity and good selectivity toward HT-29 and HeLa cell lines with IC50 values ranging from 0.12 to 0.85 μM as compared with DHA (dihydroartemisinin). Compounds 10a and 11a are most active toward HeLa cells with IC50 values of 0.12 and 0.19 μM. The results revealed that the presence of chalcone moiety is beneficial to their activity and selectivity. In addition, compounds 12a-12h containing a 'reversed chalcone' moiety showed only slight improvement in activity than those of DHA. Three new series of artemisinin-chalcone hybrids (10a-10g, 11a-11g and 12a-12h) were synthesized and evaluated for their anti-tumor activity against five human cancer cell lines. Copyright
