151204-56-7

Basic information

• Product Name: (1alpha,2alpha)-crinan-1,2-diol
• CAS NO: 151204-56-7
• Molecular Formula: C₁₆H₁₉NO₄
• Molecular Weight: 289.3264
• Mol File: 151204-56-7.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 469.1°C at 760 mmHg
• Flash Point: 237.5°C
• Density: 1.49g/cm³
• Vapor Pressure: 1.33E-09mmHg at 25°C
• Refractive Index: 1.705
• CAS DataBase Reference: (1alpha,2alpha)-crinan-1,2-diol(CAS DataBase Reference)
• NIST Chemistry Reference: (1alpha,2alpha)-crinan-1,2-diol(151204-56-7)
• EPA Substance Registry System: (1alpha,2alpha)-crinan-1,2-diol(151204-56-7)

Safety Data

• Hazardous Substances Data: 151204-56-7(Hazardous Substances Data)

Usage

General Description

(1alpha,2alpha)-crinan-1,2-diol is a chemical compound with the molecular formula C20H29NO3 and a molecular weight of 331.45 g/mol. It is a diol, meaning it contains two hydroxyl (-OH) groups, and is classified as a crinane alkaloid. Crinan-1,2-diol is derived from the crinane alkaloid family, which is found in certain plants and has various biological activities. (1alpha,2alpha)-crinan-1,2-diol has been studied for its potential pharmacological properties, including anti-inflammatory and antitumor effects. Its chemical structure and properties make it a subject of interest for further research in the fields of pharmaceuticals and natural product chemistry.

Upstream product

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Relevant articles and documents

Asymmetric Syntheses of Amaryllidaceae Alkaloids (-)-Crinane and (+)-4a-Dehydroxycrinamabine

A palladium-catalyzed asymmetric allyl-allyl cross-coupling reaction to construct the chiral quaternary carbon center of crinane alkaloids has been developed. On the basis of an efficient approach, the enantioselective synthesis of (-)-crinane (1) is presented, and the first asymmetric total synthesis of (+)-4a-dehydroxycrinamabine (2) was achieved by subsequent oxidation, 1,4-conjugate addition, RCM reaction, reductive amination, and Pictet-Spengler reaction. The method provided an alternative strategy for the syntheses of crinane alkaloids and other Amaryllidaceae natural products.

Short, efficient syntheses of the Amaryllidaceae alkaloids (-)-amabiline and (-)-augustamine via intramolecular 2-azaallyl anion cycloadditions

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A through intra-molecular to aromatization and efficient synthesis of the wenshu blue alkali and its analogue (by machine translation)

The present invention provides a through the intramolecular to aromatization and efficient synthesis of the wenshu blue alkali and analogues thereof, comprises the following 7 steps: aniline compound synthesis, synthesis of aniline compound, phenol compound synthesis, synthesis of cyclized product, two alcoholic compound synthesis, the synthesis of the compounds, grand crinum alkali and analogs thereof. The invention by transition metal-catalyzed coupling reaction in the molecule to aromatization similar biological pathways, while at the same time realize superior chemical and enantiomeric selectivity, this is biological synthesis the incomparable. This synthetic route step is short, and the product yield is high. (by machine translation)