15121-62-7

Upstream product

• 29875-08-9 3,5-dimethylbenzyl magnesium chloride 
• 123-54-6 acetylacetone 
• 2745-54-2 3,5-dimethylbenzyl chloride 

Downstream Products

• 36229-35-3 (2R,4S)-1,5-Bis-(3,5-dimethyl-phenyl)-2,4-dimethyl-pentane-2,4-diol 

Relevant academic research and scientific papers

AN IMPROVED SYNTHESIS OF HEXAMETHYLPHENALENE

The synthesis of 1,3,4,6,7,9-hexamethylphenalene (2) has been improved from 15 steps to a four step procedure.The overall yield has been increased from an estimated 5percent to 45percent.Key steps in the synthesis are the reaction of 3,5-dimethylbenzylmagnesium chloride with 2,4-pentanedioato lithium in THF to make 5-(3,5-dimethylphenyl)-4-methyl-4-hydroxy-2-pentanone (5) and the Lewis acid acylation-alkation of 1,3,6,8-tetramethylnaphthalene using 3-chlorobutanoic chloride in hexane with sonicaton to make 1,3,4,6,7,9-hexamethyl-phenalane (2).