15121-83-2Relevant academic research and scientific papers
A mild and efficient bisaldolization of ketones and its application towards spirocyclic 1,3-dioxanes and novel 1,3,5-trioxocanes
Srinivas, Nagarapu,Marrapu, Vijay K.,Bhandari, Kalpana
experimental part, p. 1346 - 1350 (2009/10/19)
Bisaldolization of aryl alkyl ketones as well as cyclic ketones with paraformaldehyde in the presence of a catalytic amount of L-proline and low concentration of aqueous sodium hydroxide has been developed in excellent yields. Further, these bisaldols are
Enantioselective enzymatic desymmetrization of prochiral 1,3-diols and enzymatic resolution of monoprotected 1,3-diols based on α-tetralone and related multifunctional scaffolds
Mahapatra, Tridib,Das, Tapas,Nanda, Samik
experimental part, p. 2497 - 2507 (2009/04/11)
Novel multifunctional chemotypes based on α-tetralone, α-indanone, and chromanone have been synthesized by a chemo-enzymatic approach by applying an enzymatic irreversible transesterification strategy. The scaffolds synthesized can be further elaborated with subsequent enzymatic as well as chemical transformations for the generation of new sets of structurally related organic molecules.
Anionic, in situ generation of formaldehyde: A very useful and versatile tool in synthesis
Deguest, Geoffrey,Bischoff, Laurent,Fruit, Corinne,Marsais, Francis
, p. 1165 - 1167 (2007/10/03)
(Chemical Equation Presented) A very simple, safe and powerful method for the in situ generation of formaldehyde at low temperature in anhydrous conditions is described. This new tool avoids the use of gaseous formaldehyde and is suitable for basic carbon nucleophiles which cannot be generated in aqueous reaction media. Various substrates, including organolithium reagents and enolates, underwent smooth hydroxymethylation showing the versatility of this process. A Wittig reaction was also carried out in high yield.
