151223-74-4

Basic information

• Product Name: 1H-Imidazole,2-bromo-2,3-dihydro-(9CI)
• Synonyms: 1H-Imidazole,2-bromo-2,3-dihydro-(9CI)
• CAS NO: 151223-74-4
• Molecular Formula: C3H5BrN2
• Molecular Weight: 0
• Product Categories: HALIDE
• Mol File: 151223-74-4.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1H-Imidazole,2-bromo-2,3-dihydro-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Imidazole,2-bromo-2,3-dihydro-(9CI)(151223-74-4)
• EPA Substance Registry System: 1H-Imidazole,2-bromo-2,3-dihydro-(9CI)(151223-74-4)

Safety Data

• Hazardous Substances Data: 151223-74-4(Hazardous Substances Data)

Usage

Imidazole derivative

A five-membered heterocyclic ring with two nitrogen atoms The compound is based on the imidazole structure, which is a fundamental heterocyclic aromatic organic compound.

Bromine atom attachment

At the carbon 2 position of the imidazole ring The compound features a bromine atom attached specifically to the second carbon atom in the imidazole ring.

Dihydro structure

A double bond reduced to a single bond The compound has undergone hydrogenation, resulting in a reduction of a double bond to a single bond within its structure.

Upstream product

• 15469-97-3 N-tritylimidazole 
• 502141-80-2 2,5-dibromo-1⁽³⁾H-imidazole-4-carboxylic acid-(4-bromo-anilide) 
• 10035-10-6 hydrogen bromide 
• 288-32-4 1H-imidazole 
• 1239205-21-0 2-bromo-N,N-dimethyl-1H-imidazole-1-sulfonamide 

Downstream Products

• 1207457-15-5 tert-butyl 2-bromo-1H-imidazole-1-carboxylate 
• 1332881-59-0 3-(1H-imidazol-2-yl)-1-(phenylsulfonyl)-1H-indole 
• 235426-32-1 1-benzyl-2-bromo-1H-imidazole 

Relevant articles and documents

Preparation method of 2-nitroimidazole

The invention discloses a preparation method of 2-nitroimidazole. The method comprises the following steps: carrying out selective bromination on imidazole as an initial raw material in an imidazole ionic liquid, introducing bromine atoms to the 2-site of the imidazole ring to generate 2-bromoimidazole, and carrying out a nitrosation reaction under the action of a catalyst to obtain 2-nitroimidazole. Based on the defects of difficultly available and expensive raw material 2-aminoimidazole sulfate, risk in use of fluoroboric acid, high copper sulfate consumption and environmental pollution caused by high copper sulfate consumption in the prior art, a new synthesis route is developed, wherein the raw materials are easy to obtain, the steps are short, the cost is low, and the method is environmentally friendly.

INHIBITORS OF POLO-LIKE KINASE

The present invention provides compounds having a structure according to Formula (I):or a salt or solvate thereof, wherein ring A, U1, U2, U3, R2, R3 and R4 are defined herein. The invention further provides pharmaceutical compositions including the compounds of the invention and methods of making and using the compounds and compositions of the invention, e.g., in the treatment and prevention of various disorders, such as Parkinson's disease.

An efficient, rapid, and regioselective bromination of anilines and phenols with 1-butyl-3-methylpyridinium tribromide as a new reagent/solvent under mild conditions

1-Butyl-3-methylpyridinium tribromide, [BMPy]Br3 proves to be a highly efficient, regioselective reagent/solvent for nuclear bromination of various anilines and phenols. The synthesis and characterization of the room temperature ionic liquid [BMPy]Br3 (2) is described. The bromination was carried out in the absence of organic solvents and in most cases the only extraction solvent needed was water. The spent 1-butyl-3-methylpyridinium bromide (1) was easily recycled.