151250-76-9

Basic information

• Product Name: N,N'-Desethylene Levofloxacin Hydrochloride
• Synonyms: N,N'-Desethylene Levofloxacin Hydrochloride;(S)-9-Fluoro-2,3-dihydro-3-Methyl-10-[[2-(MethylaMino)ethyl]aMino]-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic Acid Hydrochloride;(S)-9-fluoro-3-methyl-10- ((2-(methylamino)ethyl)amino) -7-oxo-2,3-dihydro-7H-[1,4]oxazino [2,3,4-ij]quinoline-6-carboxylic acid;N,N'-Desethylene Levofloxacin 1;(S)-9-Fluoro-2,3-dihydro-3-Methyl-10-[[2-(MethylaMino)ethyl]aMino]-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic Acid
• CAS NO: 151250-76-9
• Molecular Formula: C16H19ClFN3O4
• Molecular Weight: 371.7911632
• Product Categories: Chiral Reagents;Heterocycles;Impurities;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 151250-76-9.mol
• Article Data: 4

Chemical Properties

• Melting Point: 264-266°C
• Boiling Point: 561.8±50.0 °C(Predicted)
• Appearance: /
• Density: 1.44±0.1 g/cm3(Predicted)
• Storage Temp.: -20?C Freezer
• Solubility: DMSO (Slightly, Heated), Methanol (Slightly), Water (Slightly)
• PKA: 5.33±0.40(Predicted)
• CAS DataBase Reference: N,N'-Desethylene Levofloxacin Hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: N,N'-Desethylene Levofloxacin Hydrochloride(151250-76-9)
• EPA Substance Registry System: N,N'-Desethylene Levofloxacin Hydrochloride(151250-76-9)

Safety Data

• Hazardous Substances Data: 151250-76-9(Hazardous Substances Data)

Usage

Chemical Properties

Yellow Solid

Uses

Different sources of media describe the Uses of 151250-76-9 differently. You can refer to the following data:
1. N,N''-Desethylene Levofloxacin is an impurity of Levofloxacin (L360255). Levofloxacin is an antibiotic.
2. Levofloxacin (L360000) impurity. A photodegradation product of Levofloxacin (L360000) in aqueous solution.

Upstream product

• 100986-85-4 levofloxacin 
• 118120-51-7 Levofloxacin hydrochloride 
• 100986-89-8 levofloxacin Q-acid 

Relevant articles and documents

Visible light-driven photocatalytic degradation of organic pollutants by a novel Ag3VO4/Ag2CO3 p–n heterojunction photocatalyst: Mechanistic insight and degradation pathways

In the field of photocatalysis, the construction of a heterojunction system with efficient charge separation at the interface and charge transfer to increase the photocatalyst performance has gained considerable attention. In this study, the Ag3VO4/Ag2CO3 p–n heterojunction is first synthesized using a simple co-precipitation method. The composite photocatalyst with a p-n heterojunction has a strong internal electric field, and its strong driving force can effectively solve the problem of low separation and migration efficiency of photogenerated electron-hole pairs. The optimized Ag3VO4/Ag2CO3 composite can effectively degrade organic pollutants (rhodamine b (RhB), methylene blue (MB), levofloxacin (LVF), and tetracycline). More specifically, the Ag3VO4/Ag2CO3 photocatalyst with a 1:2 mass ratio (VC-12) can remove 97.8percent and 82percent of RhB and LVF within 30 and 60 min, respectively. The LVF degradation rate by VC-12 under visible light irradiation is more than 12.8 and 21.51 times higher than those of pure Ag3VO4 and Ag2CO3, respectively. The excellent photocatalytic activity of the Ag3VO4/Ag2CO3 hybrid system is mainly attributed to the internal electric field that forms in the Ag3VO4/Ag2CO3 p–n heterojunction system, the photogenerated electron hole pairs that separate and facilely migrate, and the specific surface area of VC-12 that is larger than that of the monomer. In addition, the degradation efficiency of VC-12 did not decline significantly after four cycles. In this study, the photocatalytic mechanism for Ag3VO4/Ag2CO3 photocatalysts is explored in detail based on the energy band analysis results, trapping experiment results, and electron spin resonance spectra. Finally, the LVF degradation products are analyzed by liquid chromatography–mass spectrometry, and the potential LVF degradation pathway is identified. The experiments performed in this research therefore lead to new motivation for the design and synthesis of highly efficient and widely applicable photocatalysts for environmental purification.

Preparation method of levofloxacin impurities

The invention relates to the field of drug synthesis, in particular to a preparation method of levofloxacin impurities. The preparation method comprises the steps of carrying out reflux of levofloxacin carboxylic acid, N-methylethylenediamine hydrochloride and triethylamine in dimethylsulfoxide, and then obtaining a levofloxacin impurity I with high purity through washing column chromatography; and heating the impurity I and acetic anhydride in formic acid, and then obtaining a levofloxacin impurity II with high purity through washing column chromatography. The preparation method has the characteristics of short synthetic route, simple and convenient operation, high product purity of the obtained impurities and the like, and can be used for researches on levofloxacin impurity reference substances and so on.