151252-98-1

Basic information

• Product Name: 2,3-Dihydro-N-benzyl-1H-inden-1-amine
• Synonyms: 2,3-Dihydro-N-(phenylmethyl)-1H-inden-1-amine;2,3-dihydro-n-benzyl-1h-inden-1-amine
• CAS NO: 151252-98-1
• Molecular Formula: C₁₆H₁₇N
• Molecular Weight: 223.31
• EINECS: 251-166-8
• Mol File: 151252-98-1.mol
• Article Data: 18

Chemical Properties

• Boiling Point: 357°C
• Flash Point: 179°C
• Appearance: /
• Density: 1.08
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.615
• PKA: 8?+-.0.20(Predicted)
• CAS DataBase Reference: 2,3-Dihydro-N-benzyl-1H-inden-1-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3-Dihydro-N-benzyl-1H-inden-1-amine(151252-98-1)
• EPA Substance Registry System: 2,3-Dihydro-N-benzyl-1H-inden-1-amine(151252-98-1)

Safety Data

• Hazardous Substances Data: 151252-98-1(Hazardous Substances Data)

Usage

General Description

2,3-Dihydro-N-benzyl-1H-inden-1-amine is a chemical compound with the molecular formula C19H21N. It is a primary aromatic amine that contains a benzyl group and an indenamine group. 2,3-Dihydro-N-benzyl-1H-inden-1-amine is commonly used in organic synthesis and pharmaceutical research due to its versatile chemical reactivity and potential pharmacological properties. It is an important building block for the synthesis of various organic compounds, and its molecular structure makes it a valuable intermediate for the preparation of pharmaceuticals and other biologically active molecules. Additionally, its unique structural features and aromatic properties make it a valuable tool for the development of new materials and chemical applications.

InChI:InChI=1/C16H17N/c1-2-6-13(7-3-1)12-17-16-11-10-14-8-4-5-9-15(14)16/h1-9,16-17H,10-12H2

Upstream product

• 34698-41-4 2,3-dihydro-1H-inden-1-amine 
• 100-44-7 benzyl chloride 
• 164020-80-8 Benzyl-[3-(2-bromo-phenyl)-prop-(E)-ylidene]-amine 
• 35275-62-8 1-chloroindane 
• 100-46-9 benzylamine 
• 124985-23-5 N-(2,3-dihydroinden-1-ylidene)(phenyl)methanamine 
• 95-13-6 1-indene 
• 107408-16-2 3-(o-bromophenyl)propanal 
• 110-89-4 piperidine 
• 78-81-9 isobutylamine 
• 83-33-0 inden-1-one 
• 1456900-60-9 N-benzyl-N-(2,3-dihydro-1H-inden-1-yl)-1,1,2,2,3,3,4,4,4-nonafluorobutane-1-sulfonamide 
• 496-11-7 INDANE 

Relevant articles and documents

Air and water stable secondary phosphine oxides as diazaphospholene precatalysts

Air-stable secondary phosphine oxides (SPOs) are readily formed from diazaphospholene bromides. In the presence of pinacolborane, these SPOs are transformed into catalytically active diazaphospholene hydrides. A silyl triflate transforms the SPOs into pho

High-Throughput Screening of Reductive Amination Reactions Using Desorption Electrospray Ionization Mass Spectrometry

This study describes the latest generation of a high-throughput screening system that is capable of screening thousands of organic reactions in a single day. This system combines a liquid handling robot with desorption electrospray ionization (DESI) mass spectrometry (MS) for a rapid reaction mixture preparation, accelerated synthesis, and automated MS analysis. A total of 3840 unique reductive amination reactions were screened to demonstrate the throughputs that are capable with the system. Products, byproducts, and intermediates were all monitored in full-scan mass spectra, generating a complete view of the reaction progress. Tandem mass spectrometry experiments were conducted to verify the identity of the products formed. The amine and electrophile reactivity trends represented in the data match what is expected from theory, indicating that the system accurately models the reaction performance. The DESI results correlated well with those generated using more traditional mass spectrometry techniques like liquid chromatography-mass spectrometry, validating the data generated by the system.

Hydroboration Catalyzed by 1,2,4,3-Triazaphospholenes

The synthesis and study of the catalytic activity of 1,2,4,3-triazaphospholenes (TAPs) is reported. TAPs represent a more modular scaffold than previously reported diazaphospholenes. TAP halides were shown to catalyze the 1,2 hydroboration of 19 imines, and three α,β unsaturated aldehydes with pinacolborane, including examples that did not undergo hydroboration by previously reported diazaphospholene systems. DFT calculations support a mechanism where a triazaphospholene cation interacts with the substrate, a mechanism distinct from diazaphospholene catalyzed hydroborations.