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151257-06-6

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151257-06-6 Usage

General Description

1,3-Diazaspiro[4.4]non-1-ene,2-butyl-(9CI) is a chemical compound with a complex and specific chemical structure. It is also known as 2-butyl-1,3-diazaspiro[4.4]non-1-ene. 1,3-Diazaspiro[4.4]non-1-ene,2-butyl-(9CI) is a spirocyclic heterocyclic compound, meaning it contains both a spiro and a heterocyclic ring. It is primarily used in the field of organic chemistry as a building block or intermediate for the synthesis of other chemical compounds. Its unique structure and properties make it suitable for various chemical reactions and transformations, making it a valuable component for the production of pharmaceuticals, agrochemicals, and other fine chemicals. Due to its specific nature, 1,3-Diazaspiro[4.4]non-1-ene,2-butyl-(9CI) is not commonly encountered outside of laboratory settings or research and development activities in the chemical industry.

Check Digit Verification of cas no

The CAS Registry Mumber 151257-06-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,1,2,5 and 7 respectively; the second part has 2 digits, 0 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 151257-06:
(8*1)+(7*5)+(6*1)+(5*2)+(4*5)+(3*7)+(2*0)+(1*6)=106
106 % 10 = 6
So 151257-06-6 is a valid CAS Registry Number.

151257-06-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-n-butyl-1,3-diazaspiro<4.4>non-1-ene

1.2 Other means of identification

Product number -
Other names 1,3-Diazaspiro[4.4]non-1-ene,2-butyl-

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:151257-06-6 SDS

151257-06-6Upstream product

151257-06-6Relevant articles and documents

A New Series of Imidazolones: Highly Specific and Potent Nonpeptide AT1 Angiotensin II Receptor Antagonists

Bernhart, Claude A.,Perreaut, Pierre M.,Ferrari, Bernard P.,Muneaux, Yvette A.,Assens, Jean-Louis A.,et al.

, p. 3371 - 3380 (1993)

Starting from the structure of the novel nonpeptide AT1 receptor antagonists DuP 753 (losartan), a new series of potent antagonists was designed.In these compounds the central imidazole nucleus was replaced by the dihydroimidazol-4-one structure.The most active compounds had a spirocyclopentane or a spirocyclohexane ring in position 5.Like the imidazole series, the best substituents were the linear butyl chain in position 2 and the methyl group in position 3.Antagonistic activity was assessed by the ability of the compounds to competively inhibit AII binding to the AT1 subtype receptor and to antagonize AII-induced contractions in rabbit aorta rings.The most active compounds had IC50 values in the nanomolar range.In conscious rats, compounds 4 and 21 antagonized the AII pressor response when administered orally.Compound 21 (SR 47436) was the most active; it was recently shown to also be active in cynomolgus monkeys both intravenously and orally.This molecule is now undergoing clinical trials for the treatment of hypertension.

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