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151258-20-7

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151258-20-7 Usage

General Description

1-(4-BromoMethyl-benzenesulfonyl)-pyrrolidine is a chemical compound with a molecular formula of C11H14BrNO2S and a molecular weight of 304.20. It is a white to off-white solid with a purity of 98% or higher. 1-(4-BroMoMethyl-benzenesulfonyl)-pyrrolidine, 98+% C11H14BrNO2S, MW: 304.20 is commonly used as a reagent in organic synthesis and pharmaceutical research. It has been found to exhibit potential biological activities and has been studied as a potential drug candidate in medicinal chemistry. Its unique structure and properties make it a valuable tool in the development of new molecules and drugs.

Check Digit Verification of cas no

The CAS Registry Mumber 151258-20-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,1,2,5 and 8 respectively; the second part has 2 digits, 2 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 151258-20:
(8*1)+(7*5)+(6*1)+(5*2)+(4*5)+(3*8)+(2*2)+(1*0)=107
107 % 10 = 7
So 151258-20-7 is a valid CAS Registry Number.

151258-20-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-[4-(bromomethyl)phenyl]sulfonylpyrrolidine

1.2 Other means of identification

Product number -
Other names 1-((4-(Bromomethyl)phenyl)sulfonyl)pyrrolidine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:151258-20-7 SDS

151258-20-7Relevant articles and documents

Synthesis and initial biological evaluation of new mimics of the LXR-modulator 22(S)-hydroxycholesterol

?strand, O. Alexander H.,Sandberg, Marcel,Sylte, Ingebrigt,G?rbitz, Carl Henrik,Thoresen, G. Hege,Kase, Eili T.,Rongved, P?l

, p. 643 - 650 (2014/01/17)

The generic, synthetic oxysterol 22(S)-hydroxycholesterol (22SHC) has shown antagonistic effects towards liver X receptor (LXR) in vitro and promising effects on plasma triacylglycerol level and body weight-gain in animal studies.1,2 On the contrary, the endogenic LXR agonist 22(R)-hydroxycholesterol (22RHC) and synthetic LXR agonists convincingly have shown agonistic effects on genes involved in lipogenesis, and inhibitory effects on cell proliferation in vitro and in vivo.3 We hypothesized that the carbon side chain containing the hydroxyl group at the 22-position was a pharmacophore affecting these opposite effects on LXR. This prompted us to initiate a rational drug design incorporating the 22-hydroxylated 20-27 cholesterol moiety into cholesterol-mimicking building blocks. The two enantiomers of the 22-hydroxylated 20-27 cholesterol moiety were synthesized with an excellent enantiomeric excess and the stereochemistry are supported by X-ray crystallography. Molecular modelling of the new compounds showed promising LXR selectivity (LXRβ over LXRα) and initial in vitro biological evaluation in human myotubes showed that compound 16b had agonistic effects on the gene expression of SCD1 and increased lipogenesis.

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