15126-07-5

Usage

Uses

Used in Pharmaceutical Industry:
ETHYL-3-IODO-4-HYDROXY BENZOATE is used as an intermediate in the synthesis of various pharmaceuticals for its antimicrobial and antioxidant properties, contributing to the development of new medications.
Used in Agrochemical Industry:
In the agrochemical field, ETHYL-3-IODO-4-HYDROXY BENZOATE is utilized as an intermediate in the production of compounds that have potential applications in medicine and agrochemicals, enhancing the effectiveness of these products.
Used in Cosmetics and Personal Care Products:
ETHYL-3-IODO-4-HYDROXY BENZOATE is used in the production of cosmetics and personal care products due to its antimicrobial properties, which help maintain product integrity and safety.
It is important to handle ETHYL-3-IODO-4-HYDROXY BENZOATE with caution, as it may be harmful if ingested or inhaled, and can cause irritation to the skin and eyes.

InChI:InChI=1/C9H9IO3/c1-2-13-9(12)6-3-4-8(11)7(10)5-6/h3-5,11H,2H2,1H3

Upstream product

• 64-17-5 ethanol 
• 37470-46-5 4-hydroxy-3-iodobenzoic acid 
• 120-47-8 Ethyl 4-hydroxybenzoate 
• 99-96-7 4-hydroxy-benzoic acid 
• 1571-72-8 3-amino-4-hydroxybenzoic acid 

Downstream Products

• 460720-57-4 ethyl 4-(benzyloxy) 3-iodobenzoate 
• 75552-00-0 3-Aminomethyl-4-hydroxy-5-iodo-benzoic acid ethyl ester; hydrochloride 
• 861398-62-1 ethyl 3-iodo-4-{[(2E)-4-phenyl-but-2-enyl]oxy}benzoate 
• 207115-38-6 ethyl 3-iodo-4-methoxybenzoate 
• 105401-94-3 ethyl 4-methoxy-3,5-dimethylbenzoate 
• 101096-65-5 3-iodo-4-phenoxybenzoic acid ethyl ester 
• 939051-02-2 ethyl 3-cyano-4-trifluoromethanesulfonyloxybenzoate 
• 34133-59-0 ethyl 4-hydroxy-3-cyanobenzoate 

Relevant academic research and scientific papers

Pd-Catalyzed ipso, meta-Dimethylation of ortho-Substituted Iodoarenes via a Base-Controlled C-H Activation Cascade with Dimethyl Carbonate as the Methyl Source

A methyl group can have a profound impact on the pharmacological properties of organic molecules. Hence, developing methylation methods and methylating reagents is essential in medicinal chemistry. We report a palladium-catalyzed dimethylation reaction of ortho-substituted iodoarenes using dimethyl carbonate as a methyl source. In the presence of K2CO3 as a base, iodoarenes are dimethylated at the ipso- and meta-positions of the iodo group, which represents a novel strategy for meta-C-H methylation. With KOAc as the base, subsequent oxidative C(sp3)-H/C(sp3)-H coupling occurs; in this case, the overall transformation achieves triple C-H activation to form three new C-C bonds. These reactions allow expedient access to 2,6-dimethylated phenols, 2,3-dihydrobenzofurans, and indanes, which are ubiquitous structural motifs and essential synthetic intermediates of biologically and pharmacologically active compounds.

Relay Cross Metathesis for the Iterative Construction of Terpenoids and Synthesis of a Diterpene-Benzoate Macrolide of Biogenetic Relevance to the Bromophycolides

We report a relay cross metathesis (ReXM) reaction for the construction of terpenoids in an iterative protocol. The protocol features the cross metathesis of a relay-actuated Δ6,7-functionalized C10-monoterpenoid alcohol with C10-monoterpenoid citral to form a C15-sesquiterpene. Subsequent functional group manipulation allows for the method to be repeated in an iterative fashion. The method is used for the synthesis of a diterpene-benzoate macrolide of biogenetic relevance to the bromophycolide family of natural products.

Oxyacylation of Iodoalkynes: Gold(I)-Catalyzed Expeditious Access to Benzofurans

(Acetonitrile)[1,3-bis(2,6-diisopropylphenyl)-imidazole-2-ylidene] gold(I) catalyzes the cycloisomerization of 2-(iodoethynyl)aryl esters to give 3-iodo-2-acyl benzofurans. This catalytic transformation is the result of an unprecedented selective syntheti

Synthesis and evaluation of 1,2,4-methyltriazines as mGluR5 antagonists

In previous studies we showed that 3-(substituted phenylethynyl)-5- methyl[1,2,4]triazine analogues of MPEP were potent antagonists of glutamate-mediated mobilization of internal calcium in an mGluR5 in vitro efficacy assay. In the present study we report

AMPA RECEPTOR POTENTIATORS

The present invention relates to a compound of Formula (I) or a pharmaceutically acceptable salt thereof which is useful for the treatment of conditions associated with glutamate hypofunction, such as psychiatric and neurological disorders.

Pd-catalyzed copper-free carbonylative Sonogashira reaction of aryl iodides with alkynes for the synthesis of alkynyl ketones and flavones by using water as a solvent

The Pd-catalyzed copper-free carbonylative Sonogashira coupling reaction to synthesize alkynyl ketones from terminal alkynes and aryl iodides was achieved by using water as a solvent. The reaction was carried out at room temperature under balloon pressure of CO with Et3N as a base. The developed method was successfully applied to the synthesis of flavones.