1512624-50-8Relevant articles and documents
Potent hepatitis C virus NS5A inhibitors containing a benzidine core
Bae, Il Hak,Choi, Jin Kyu,Chough, Chieyeon,Keum, Sun Ju,Kim, Heesun,Jang, Sung Key,Kim, B. Moon
, p. 255 - 258 (2014/04/03)
Here we report the discovery of a series of potent hepatitis C virus (HCV) NS5A inhibitors based on the benzidine prolinamide backbone. Taking a simple synthetic route, we developed a novel inhibitor structure, which allows easy modification, and through optimization of the capping group, we identified compound 6 with highly potent anti-HCV activity. Compound 6 is nontoxic and is anticipated to be an effective HCV drug candidate.