15128-88-8

Basic information

• Product Name: 3-Pyridinol, 5-methyl-2-nitro-
• Synonyms: 3-Pyridinol, 5-methyl-2-nitro-;3-Hydroxy-5-methyl-2-nitropyridine;5-Methyl-2-nitropyridin-3-ol
• CAS NO: 15128-88-8
• Molecular Formula: C₆H₆N₂O₃
• Molecular Weight: 154.13
• Mol File: 15128-88-8.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 3-Pyridinol, 5-methyl-2-nitro-(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Pyridinol, 5-methyl-2-nitro-(15128-88-8)
• EPA Substance Registry System: 3-Pyridinol, 5-methyl-2-nitro-(15128-88-8)

Safety Data

• Hazardous Substances Data: 15128-88-8(Hazardous Substances Data)

Usage

General Description

5-Methyl-2-nitro-3-pyridinol is an organic compound with the chemical formula C6H6N2O3. It is a nitro pyridine derivative with a methyl group attached to the 5th position of the pyridinol ring. 3-Pyridinol, 5-methyl-2-nitro- is used in the synthesis of pharmaceuticals and agrochemicals. It has also been studied for its potential use as a corrosion inhibitor. The nitro group present in 5-methyl-2-nitro-3-pyridinol makes it a versatile building block for the synthesis of various organic compounds with potential industrial and pharmaceutical applications.

Upstream product

• 42732-49-0 5-methyl-3-pyridinol 

Downstream Products

• 20348-17-8 5-methyl-2-amino-3-pyridinol 
• 1415500-86-5 3-(cyclohexylmethoxy)-5-methyl-2-nitropyridine 
• 1415500-89-8 ethyl 8-(cyclohexylmethoxy)-2,6-dimethylimidazo[1,2-a]pyridine-3-carboxylate 
• 1415500-87-6 3-(cyclohexylmethoxy)-5-methylpyridin-2-amine 

Relevant articles and documents

SUBSTITUTED IMIDAZO[1,2-A]PYRIDINECARBOXAMIDES AND THEIR USE

The present application relates to novel substituted imidazo[1,2-a]pyridine-3-carboxamides, to processes for preparation thereof, to the use thereof, alone or in combinations, for treatment and/or prophylaxis of diseases, and to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially for treatment and/or prophylaxis of cardiovascular disorders.

Antiulcer Agents. 2. Gastric Antisecretory, Cytoprotective, and Metabolic Properties of Substituted Imidazolpyridines and Analogues

The search for a successor to 3-(cyanomethyl)-2-methyl-8-(phenylmethoxy)imidazopyridine, Sch 28080 (27), a compound that exhibits gastric antisecretory and cytoprotective properties and has undergone clinical evaluation as an antiulcer agent, has culminated in the identification of four related compounds that exhibit pharmacologic profiles similar to that of 27.In three of these potential successors an amino group functions as a surrogate for the 3-cyanomethyl substituent of the prototype.The present work concerns, in addition to an evaluation of the structure-activity relationships of a series of analogues of 27, preliminary studies of the pharmacodynamics and metabolism of 27, performed with the aid of cyano carbon labeled versions of the drug (13C labeled; 28; 14C labeled, 29).These studies have shown that 27 is well-absorbed and extensively metabolized and that the major metabolite of 27 is the thiocyanate anion.A similar study performed on 3-amino-2-methyl-8-(phenylmethoxy)imidazopyridine, labeled at the 3-position with carbon-13 (41) or carbon-14 (42), revealed that this compound, which has an antisecretory/cytoprotective profile comparable to that of 27, is also metabolized to thiocyanate anion, although this must occur via a different mechanism.The chemistry section includes a discussion of the potential sites of protonation of the pharmacologically similar 3-amino analogue 40 and the structurally related imidazopyrazine 67.Predictions based on charge density and protonation product stabilities are presented.That N1 is the site of protonation in these analogues has been definitively demonstrated by X-ray crystal structure analysis, which alsounequivocally established the assigned imidazopyrazine ring structure.