151293-15-1

Basic information

• Product Name: 5-Amino-3-(4-methylphenyl)pyrazole
• Synonyms: 5-AMINO-3-(4-METHYLPHENYL)PYRAZOLE;5-P-TOLYL-2H-PYRAZOL-3-YLAMINE
• CAS NO: 151293-15-1
• Molecular Formula: C₁₀H₁₁N₃
• Molecular Weight: 173.21
• Mol File: 151293-15-1.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 438 °C at 760 mmHg
• Flash Point: 248.8 °C
• Appearance: /
• Density: 1.196 g/cm³
• Vapor Pressure: 7.15E-08mmHg at 25°C
• Refractive Index: 1.643
• CAS DataBase Reference: 5-Amino-3-(4-methylphenyl)pyrazole(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Amino-3-(4-methylphenyl)pyrazole(151293-15-1)
• EPA Substance Registry System: 5-Amino-3-(4-methylphenyl)pyrazole(151293-15-1)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 151293-15-1(Hazardous Substances Data)

Usage

General Description

5-Amino-3-(4-methylphenyl)pyrazole is a chemical compound with the molecular formula C10H10N4. It is a pyrazole derivative, which is a class of compounds known for their diverse biological activities. This specific compound has a 5-aminopyrazole core, with a 4-methylphenyl group attached at the 3-position. Its structure suggests potential applications in medicinal chemistry, as pyrazoles are often used as building blocks for synthesis of pharmaceutical compounds. The presence of an amine and an aromatic moiety in the molecule also indicates potential for interactions with biological targets, making it a valuable compound for research and development in drug discovery and other areas of chemical biology.

InChI:InChI=1/C10H11N3/c1-7-2-4-8(5-3-7)9-6-10(11)13-12-9/h2-6H,1H3,(H3,11,12,13)

Upstream product

• 17196-75-7 3-amino-3-p-tolylacrylonitrile 
• 614-16-4 Benzoylacetonitrile 
• 7391-28-8 p-tolueneacetonitrile 
• 99-75-2 4-methyl-benzoic acid methyl ester 
• 78583-85-4 (E)-3-Chloro-3-p-tolyl-acrylonitrile 

Downstream Products

• 1123877-32-6 2-ethylsulfanyl-7-(4-methylphenyl)-4-phenylpyrazolo[1,5-a][1,3,5]triazine 
• 1029087-05-5 N-(1-acetyl-5-p-tolyl-1H-pyrazol-3-yl)acetamide 
• 664972-58-1 C₂₆H₂₁N₃O₂S 
• 1061704-94-6 C₁₆H₁₇N₃O 
• 1061704-73-1 C₂₀H₂₅N₃O₄ 
• 1141401-71-9 N-(3-p-tolyl-1H-pyrazol-5-yl)-2-mercaptoacetamide 
• 1235885-48-9 C₂₃H₁₇N₃ 
• 1353682-58-2 ethyl 2-(4-methylphenyl)-5-phenyl-6,7-dihydropyrazolo[1,5-a]pyrimidine-7-carboxylate 
• 1353682-57-1 ethyl 5-(4-bromophenyl)-2-(4-methylphenyl)-6,7-dihydropyrazolo[1,5-a]pyrimidine-7-carboxylate 
• 1353682-56-0 methyl 5-(4-methoxyphenyl)-2-(4-methylphenyl)-6,7-dihydropyrazolo[1,5-a]pyrimidine-7-carboxylate 
• 1393379-08-2 5-methyl-2-(4-methylphenyl)-7-phenyl-4,7-dihydropyrazolo[1,5-a]pyrimidine 
• 1393379-14-0 2-(4-methylphenyl)-6,8,9-triphenyl-4,7,8,9-tetrahydropyrazolo[5,1-b]quinazoline 
• 333325-14-7 4-fluoro-N-(3-(p-tolyl)-1H-pyrazol-5-yl)benzamide 
• 1575717-87-1 4-(4-nitrophenyl)-3-(4-tolyl)-1H-benzo[h]pyrazolo[3,4-b]quinolin-5,6-dione 

Relevant articles and documents

Molecular docking design and one-pot expeditious synthesis of novel 2,5-diarylpyrazolo[1,5-a]pyrimidin-7-amines as anti-inflammatory agents

Abstract A series of novel 2,5-diarylpyrazolo[1,5-a]pyrimidin-7-amines were designed as COX-2 inhibitors by molecular docking studies and their synthesis was accomplished via an expeditious one-pot reaction. Structures of the compounds were established by

Synthesis of pyrazolo[5′,1′:2,3]pyrimido[4,5-b][1,4]- benzoxazines, a new heterocyclic ring system from 5(3)-aminopyrazoles

A series of pyrazolo[5′,1′:2,3]pyrimido[4,5-b][1,4]benzoxazines (4a-n), a new heterocyclic ring system has been synthesized starting from 2H-3-oxo-[1,4]-benzoxazines (1a-d) and 5(3)-aminopyrazoles (3a-d) via the intermediates 3-chloro-2-formylidine-1,4-be

Study of regioselectivity of reactions between 3(5)-aminopyrazoles and 2-acetylcycloalkanones

Regioselectivity was examined of reactions between nine 3(5)-aminopyrazoles and 2-acetylcyclopentanone and 2-acetylcyclohexanone under various conditions. A series of cyclopenta[e]pyrazolo-[1,5-a]pyrimidines was obtained. The highest regioselectivity of the reaction was observed in alcohol at 20°C in the presence of a catalytic quantity of trifl uoroacetic acid. The regiostructure of compounds was established by 1H and 13C NMR spectroscopy. Pleiades Publishing, Ltd., 2012.

A clean and rapid synthesis of 5-amino and 5-alkoxycarbonylpyrazoles using montomorillonite under acid free conditions

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