151294-93-8

Basic information

• Product Name: TERT-BUTYL 2-(TERT-BUTOXYCARBONYLAMINO)HEX-5-ENOATE
• Synonyms: TERT-BUTYL 2-(TERT-BUTOXYCARBONYLAMINO)HEX-5-ENOATE
• CAS NO: 151294-93-8
• Molecular Formula: C₁₅H₂₇NO₄
• Molecular Weight: 285.381
• Mol File: 151294-93-8.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 371.086 °C at 760 mmHg
• Flash Point: 178.227 °C
• Appearance: /
• Density: 0.993 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.457
• Storage Temp.: 2-8°C
• PKA: 11.14±0.46(Predicted)
• CAS DataBase Reference: TERT-BUTYL 2-(TERT-BUTOXYCARBONYLAMINO)HEX-5-ENOATE(CAS DataBase Reference)
• NIST Chemistry Reference: TERT-BUTYL 2-(TERT-BUTOXYCARBONYLAMINO)HEX-5-ENOATE(151294-93-8)
• EPA Substance Registry System: TERT-BUTYL 2-(TERT-BUTOXYCARBONYLAMINO)HEX-5-ENOATE(151294-93-8)

Safety Data

• Hazardous Substances Data: 151294-93-8(Hazardous Substances Data)

Usage

General Description

TERT-BUTYL 2-(TERT-BUTOXYCARBONYLAMINO)HEX-5-ENOATE is a chemical compound that is commonly used in organic synthesis and pharmaceutical research. It is a derivative of tert-butyl carbamate and hex-5-enoic acid, and is often utilized as a protecting group for amino acids in peptide synthesis. TERT-BUTYL 2-(TERT-BUTOXYCARBONYLAMINO)HEX-5-ENOATE is also known for its ability to serve as an intermediate in the production of various pharmaceuticals and agrochemicals. Additionally, it is important to handle this compound with care, as it is known to be potentially harmful if ingested or comes into direct contact with the skin.

InChI:InChI=1/C15H27NO4/c1-8-9-10-11(12(17)19-14(2,3)4)16-13(18)20-15(5,6)7/h8,11H,1,9-10H2,2-7H3,(H,16,18)

Upstream product

• 5162-44-7 1-bromo-4-butene 
• 111652-20-1 N-(tert-butoxycarbonyl)glycine tert-butyl ester 
• 1779-49-3 Methyltriphenylphosphonium bromide 
• 194656-73-0 (S)-1-tert-butyl 2-[bis-(tert-butoxycarbonyl)amino]-5-oxopentanoate 
• 141943-64-8 (±)-2-acetamidohex-5-enoic acid 
• 122471-00-5 acetylamino-3-butenyl-propanedioic acid diethyl ester 
• 16258-05-2 D,L-2-amino-5-hexenoic acid 
• 98946-18-0 tert-Butyl 2,2,2-trichloroacetimidate 
• 214206-61-8 2-tert-butoxycarbonylamino-hex-5-enoic acid 

Downstream Products

• 220243-81-2 (+/-)-tert-butyl 2-[(tert-butoxycarbonyl)amino]-6-hydroxyhexanoate 
• 220243-56-1 (+/-)-tert-butyl 2-[(tert-butoxycarbonyl)amino]-4-(2-oxiranyl)butanoate 
• 103-30-0 (E)-1,2-diphenyl-ethene 

Relevant articles and documents

HEPATITIS C VIRUS INHIBITORS

The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit RNA-containing virus, particularly the hepatitis C virus (HCV). Consequently, the compounds of the present invention

Beta-amino acid derivatives useful for the treatment of bacterial infections

The invention provides compounds that are useful for the treatment of bacterial infections in mammals. More specifically, it is directed to beta-amino acid derivatives or pharmaceutically acceptable salts, prodrugs, or isomers of those compounds that are

Cross-metathesis of unsaturated α-amino acid derivatives

Cross-metathesis of homoallylglycine derivatives with aryl- and alkyl-substituted alkenes using the ruthenium catalyst (Cy3P)2Cl2Ru=CHPh 1 has been achieved in 43-55 and 55-66% yield respectively. Allylglycine, vinylglycine and dehydroalanine derivatives have also been examined. Whilst cross-metathesis of allylglycine derivatives with alkyl-substituted alkenes using catalyst 1 may be regarded as a synthetically useful procedure, cross-metathesis reactions of vinylglycine and dehydroalanine derivatives using catalyst 1 are non-viable. Attachment of FmocHagOH 13 to a capped Wang resin, cross-metathesis with dodec-1-ene, and product removal from the resin gives the cross-metathesis product in 74% yield based on FmocHagOH.