151338-11-3

Basic information

• Product Name: N-TERT-BUTYL 3-CYANOANDROSTA-3,5-DIENE-17-CARBOXAMIDE
• Synonyms: N-TERT-BUTYL 3-CYANOANDROSTA-3,5-DIENE-17-CARBOXAMIDE;3-cyano-N-(1,1-dimethylethyl)androsta-3,5-diene-17-β-carboxamide
• CAS NO: 151338-11-3
• Molecular Formula: C₂₅H₃₆N₂O
• Molecular Weight: 380.57
• EINECS: 415-730-9
• Mol File: 151338-11-3.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 568.7±50.0 °C(Predicted)
• Appearance: /
• Density: 1.08±0.1 g/cm3(Predicted)
• PKA: 16.10±0.70(Predicted)
• CAS DataBase Reference: N-TERT-BUTYL 3-CYANOANDROSTA-3,5-DIENE-17-CARBOXAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N-TERT-BUTYL 3-CYANOANDROSTA-3,5-DIENE-17-CARBOXAMIDE(151338-11-3)
• EPA Substance Registry System: N-TERT-BUTYL 3-CYANOANDROSTA-3,5-DIENE-17-CARBOXAMIDE(151338-11-3)

Safety Data

• Hazard Codes: N
• Statements: 50/53
• Safety Statements: 60-61
• Hazardous Substances Data: 151338-11-3(Hazardous Substances Data)

Upstream product

• 2942-58-7 diethyl cyanophosphonate 
• 131267-80-6 N-(1,1-dimethylethyl)-3-oxoandrost-4-ene-17β-carboxamide 
• 153002-81-4 3-cyano-androsta-3,5-diene-17β-carboxylic acid 
• 75-64-9 tert-butylamine 

Downstream Products

• 119169-78-7 epristeride 

Relevant articles and documents

Steroid derivatives for the treatment of prostatic hypertrophy their preparation and uses

The invention includes compounds of formula (I): STR1 in which R1 is hydrogen, alkyl, aryl-substituted alkyl or aromatic heterocyclic-substituted alkyl; R2 is aryl-substituted alkyl, aromatic heterocyclic-substituted alkyl or diarylamino; and R3 is carboxy or a group of formula --CONHSO2 R4 wherein R4 is alkyl; and pharmaceutically acceptable salts and esters of the compounds. The compounds have valuable 5α-reductase inhibitory activity and can thus be used for the treatment and prophylaxis of, inter alia, prostatic hypertrophy as well as other disorders arising from excess levels of 5α-dihydro-testosterone.