151342-35-7 Usage
Uses
Bisindolylmaleimide XI is a potent and selective cell-permeable protein kinase C (PKC) inhibitor. Studies reveal that inhibition of PKCα by Bisindolylmaleimide XI and other similar PKC inhibitors has
been associated with enhanced cardiac contractility and protection from heart failure. Bisindolylmaleimide XI has been shown to prevent T-cell activation and proliferation associated with chronic infl
ammatory responses in vivo.
Biological Activity
Selective cell-permeable protein kinase C inhibitor. Displays slight selectivity for conventional PKC isoforms over Ca 2+ and atypical PKC isoforms; binding affinities for rat isoforms are 9, 28, 31, 37 and 108 nM for PKC's α , β Ι, β ΙΙ, γ and ε respectively. Orally available and prevents T-cell chronic inflammation in vivo .
Check Digit Verification of cas no
The CAS Registry Mumber 151342-35-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,1,3,4 and 2 respectively; the second part has 2 digits, 3 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 151342-35:
(8*1)+(7*5)+(6*1)+(5*3)+(4*4)+(3*2)+(2*3)+(1*5)=97
97 % 10 = 7
So 151342-35-7 is a valid CAS Registry Number.
InChI:InChI=1/C28H28N4O2.ClH/c1-30(2)15-17-10-11-32-20(12-17)13-18-8-9-19(14-24(18)32)25-26(28(34)29-27(25)33)22-16-31(3)23-7-5-4-6-21(22)23;/h4-9,13-14,16-17H,10-12,15H2,1-3H3,(H,29,33,34);1H
151342-35-7Relevant articles and documents
Inhibitors of protein kinase C. 3. Potent and highly selective bisindolylmaleimides by conformational restriction
Bit,Davis,Elliott,Harris,Hill,Keech,Kumar,Lawton,Maw,Nixon,Vesey,Wadsworth,Wilkinson
, p. 21 - 29 (2007/10/02)
The protein kinase inhibitor staurosporine has been used to design a series of selective bisindolylmaleimide inhibitors of protein kinase C (PKC). Guided by molecular graphics, conformational restriction of the cationic side chain has led to ATP competiti
